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Concomitant herpetic keratitis and acute retinal necrosis: clinical features and outcomes
Eye ( IF 2.8 ) Pub Date : 2020-02-24 , DOI: 10.1038/s41433-020-0826-z
Wendy Ming 1 , Nikhil Dewan 1, 2 , Sonia N Yeung 1 , Alfonso Iovieno 1
Affiliation  

Background/Objectives The aim of this study was to identify risk factors, prognosis, and management in patients with concomitant herpetic keratitis and acute retinal necrosis (ARN). Subjects/Methods In this retrospective observational series, ARN patients in the Greater Vancouver area from 2004 to 2018 were identified through key words, billing codes, and dispensing data from medical records of affiliate researchers and the pharmacy at Vancouver General Hospital. Results Twenty-eight patients were diagnosed with ARN during this period. Five of those were also diagnosed with herpetic keratitis. Thus, the incidence of combined keratitis and ARN was 18% of patients with ARN. The two diseases occurred concomitantly in four out of five patients. Mean age at diagnosis was 55 ± 17 years. Of the five patients with both corneal and retinal involvement, three patients were immunocompromised and three had a history of herpetic diseases. Three developed disciform keratitis and two developed stromal immune keratitis. Clinical management and outcomes of these patients did not differ from patients with ARN alone, except for a lower rate of retinal detachment ( p = 0.006) and a higher proportion with visual acuity ≥ 20/200 ( p = 0.01). Conclusions Keratitis may complicate the clinical picture of one out of five to six patients with ARN. Comprehensive ophthalmic examination, including careful anterior segment exams in patients with ARN and sequential dilated fundus exams in patients with herpetic keratitis, should always be conducted to identify cases of concomitant disease.

中文翻译:

伴随疱疹性角膜炎和急性视网膜坏死:临床特征和结果

背景/目的 本研究的目的是确定伴发疱疹性角膜炎和急性视网膜坏死 (ARN) 的患者的危险因素、预后和管理。受试者/方法在这个回顾性观察系列中,通过关键词、账单代码和来自附属研究人员和温哥华综合医院药房的医疗记录的配药数据,确定了 2004 年至 2018 年大温哥华地区的 ARN 患者。结果 在此期间,28 名患者被诊断为 ARN。其中五人还被诊断出患有疱疹性角膜炎。因此,合并角膜炎和 ARN 的发生率为 ARN 患者的 18%。这两种疾病在五分之四的患者中同时发生。诊断时的平均年龄为 55 ± 17 岁。在角膜和视网膜均受累的 5 名患者中,三名患者免疫功能低下,三名患者有疱疹病史。三个发展成盘状角膜炎,两个发展成基质免疫性角膜炎。除了视网膜脱离率较低 (p = 0.006) 和视力 ≥ 20/200 的比例较高 ( p = 0.01) 外,这些患者的临床管理和结果与单独 ARN 患者没有区别。结论 角膜炎可能会使五到六名 ARN 患者中就有 1 人的临床表现复杂化。应始终进行全面的眼科检查,包括对 ARN 患者进行仔细的眼前节检查和对带状疱疹性角膜炎患者进行连续的散瞳眼底检查,以识别伴随疾病的病例。三个发展成盘状角膜炎,两个发展成基质免疫性角膜炎。除了视网膜脱离率较低 (p = 0.006) 和视力 ≥ 20/200 的比例较高 ( p = 0.01) 外,这些患者的临床管理和结果与单独 ARN 患者没有区别。结论 角膜炎可能会使五到六名 ARN 患者中就有 1 人的临床表现复杂化。应始终进行全面的眼科检查,包括对 ARN 患者进行仔细的眼前节检查和对带状疱疹性角膜炎患者进行连续的散瞳眼底检查,以识别伴随疾病的病例。三个发展成盘状角膜炎,两个发展成基质免疫性角膜炎。除了视网膜脱离率较低 (p = 0.006) 和视力 ≥ 20/200 的比例较高 ( p = 0.01) 外,这些患者的临床管理和结果与单独 ARN 患者没有区别。结论 角膜炎可能会使五到六名 ARN 患者中就有 1 人的临床表现复杂化。应始终进行全面的眼科检查,包括对 ARN 患者进行仔细的眼前节检查和对带状疱疹性角膜炎患者进行连续的散瞳眼底检查,以识别伴随疾病的病例。006) 和更高比例的视力 ≥ 20/200 ( p = 0.01)。结论 角膜炎可能会使五到六名 ARN 患者中就有 1 人的临床表现复杂化。应始终进行全面的眼科检查,包括对 ARN 患者进行仔细的眼前节检查和对带状疱疹性角膜炎患者进行连续的散瞳眼底检查,以识别伴随疾病的病例。006) 和更高比例的视力 ≥ 20/200 ( p = 0.01)。结论 角膜炎可能会使五到六名 ARN 患者中就有 1 人的临床表现复杂化。应始终进行全面的眼科检查,包括对 ARN 患者进行仔细的眼前节检查和对带状疱疹性角膜炎患者进行连续的散瞳眼底检查,以识别伴随疾病的病例。
更新日期:2020-02-24
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