Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease which increases the lysosomal degradation of low density lipoprotein receptor (LDLR) resulting in elevated serum LDL-cholesterol levels. Elevated LDL-cholesterol is the main risk factor for cardiovascular disease (CVD). Antibodies to PCSK9 decrease LDL-cholesterol. Recent studies have suggested a direct relationship between PCSK9 and inflammation and the potential inhibitory effects of anti-inflammatory agents against this enzyme. Nutraceuticals are natural compounds, which have numerous anti-inflammatory and lipid-lowering effects. In this review we focus on anti-inflammatory substances and nutraceuticals, which are beneficial in treatment of dyslipidemia. We also reviewed the recent findings concerning the role of PCSK9 as the main target for molecular mechanisms of these substances.

中文翻译：

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是抗炎药和保健食品-PCSK9的新型抑制剂吗？

前蛋白转化酶枯草杆菌蛋白酶/ kexin类型9（PCSK9）是一种蛋白酶，可增加低密度脂蛋白受体（LDLR）的溶酶体降解，导致血清LDL-胆固醇水平升高。LDL-胆固醇升高是心血管疾病（CVD）的主要危险因素。PCSK9抗体可降低LDL-胆固醇。最近的研究表明，PCSK9与炎症之间存在直接的关系，而消炎剂对该酶的潜在抑制作用。营养品是天然化合物，具有多种消炎和降脂作用。在这篇综述中，我们集中于抗炎物质和营养保健品，它们对血脂异常的治疗有益。