To reach a high separation efficiency using Centrifugal Partition Chromatography (CPC), the fluid dynamical behavior of the liquid-liquid two-phase systems must be clearly understood. The fluid dynamics, namely the dispersion, the coalescence, and the stationary phase retention, have a high impact on a separation. Especially the mobile phase dispersion influences the mass transfer during a separation. In this study, the mobile phase dispersion of different aqueous-organic solvent systems was characterized for ascending and descending mode via video analysis. Thereby the influence of the physical properties of the solvent systems, the operating parameters, and the geometry of the chamber inlet was investigated systematically using dimensional analysis. With the help of the dimensionless numbers Ohnesorge number (OhCPC), Eötvös number (EoCPC), and Weber number (WeCPC) the impact of the solvent system, the plant parameters, and the operating parameters on the mobile phase dispersion could be described. Inside the three dimensional area, spanned by the dimensionless numbers, each state of mobile phase dispersion (undispersed, low dispersed, highly dispersed, and atomized) could be allocated to an individual region for both operating modes. Moreover, differences in mobile phase deflection depending on the operating mode and a possible reason for these were described.

中文翻译：

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离心分配色谱法中水性有机溶剂体系流动相分散的表征和相关性。

为了使用离心分配色谱（CPC）达到高分离效率，必须清楚地了解液-液两相系统的流体动力学行为。流体动力学（即分散，聚结和固定相保留）对分离有很大影响。特别是流动相的分散会影响分离过程中的传质。在这项研究中，通过视频分析，表征了不同水性有机溶剂体系的流动相分散体的上升和下降模式。因此，使用尺寸分析系统地研究了溶剂系统的物理性质，操作参数和室入口几何形状的影响。借助无数数Ohnesorge数（OhCPC），Eötvös数（EoCPC），韦伯数（WeCPC）可以描述溶剂系统，工厂参数和操作参数对流动相分散度的影响。在三维区域内，由无因次数所覆盖，可以将两种状态的流动相分散态（未分散，低分散，高度分散和雾化）分配给单个区域。此外，还描述了取决于工作模式的流动相挠度差异及其可能的原因。和雾化）可分配给两种操作模式的单个区域。此外，还描述了取决于工作模式的流动相挠度差异及其可能的原因。和雾化）可分配给两种操作模式的单个区域。此外，还描述了取决于工作模式的流动相挠度差异及其可能的原因。