Ynamides enabled 6-, 7-, and 8-endo-dig iodocyclization of ethoxyethyl ethers: rapid construction of medium-sized oxacycles at room temperature,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ynamides enabled 6-, 7-, and 8-endo-dig iodocyclization of ethoxyethyl ethers: rapid construction of medium-sized oxacycles at room temperature
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020/02/24 , DOI: 10.1039/d0qo00153h
Takashi Okitsu _{1,

2,

3} , Akihiro Namura _{1,

2,

3} , Shinji Kondo _{1,

2,

3} , Shoya Tada _{1,

2,

3} , Marina Yanagida _{1,

2,

3} , Akimori Wada _{1,

2,

3}

Affiliation

Iodocyclization of ethoxyethyl ethers to ynamides was developed to form six, seven-, and eight-membered cyclic ethers. These reactions reached completion within short reaction times (3 s to 3 h) at room temperature, and the cyclized products were obtained in good to quantitative yields. This is the first report of the construction of medium-sized oxacycles resulting from the iodocyclization of ynamides.

中文翻译：