Valuable chiral alcohols have been obtained from racemic mixtures with an integrated heterogeneous chemoenzymatic catalyst in a two consecutive fixed catalytic bed continuous reactor system. In the first bed the racemic mixture of alcohols is oxidized to the prochiral ketone with a Zr-Beta zeolite and using acetone as the hydrogen acceptor. In the second catalytic bed the prochiral ketone is stereoselectively reduced with an alcohol dehydrogenase (ADH) immobilized on a two dimensional (2D) zeolite. In this process, the alcohol (isopropanol) formed by the reduction of acetone in the first step reduces the cofactor in the second step, and the full reaction cycle is in this way internally closed with 100% atom economy. A conversion of about 95% with ∼100% selectivity to either the (R) or the (S) alcohol has been obtained for a variety of racemic mixtures of alcohols.

中文翻译：

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在固定床连续操作中通过集成的多相化学酶催化从外消旋混合物生产手性醇

在两个连续的固定催化床连续反应器系统中，从与外消旋混合物与集成的非均相化学酶催化剂中获得了有价值的手性醇。在第一床中，外消旋的醇混合物用Zr-β沸石并使用丙酮作为氢受体氧化为前手性酮。在第二个催化床中，用固定在二维（2D）沸石上的醇脱氢酶（ADH）选择性立体还原前手性酮。在该方法中，第一步中通过丙酮还原而形成的醇（异丙醇）在第二步中还原了辅因子，因此整个反应循环以内部100％的经济性被内部封闭。到（R）或（S对于多种外消旋醇混合物，已经获得了醇。