Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions,Nanoscale

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Length feature of ssDNA adsorption onto graphene oxide with both large unoxidized and oxidized regions
Nanoscale ( IF 5.8 ) Pub Date : 2020/02/24 , DOI: 10.1039/c9nr10170e
Xiaoling Lei _{1,

2,

3,

4,

5} , Huishu Ma _{4,

6,

7,

8,

9} , Haiping Fang _{1,

2,

3,

4,

5}

Affiliation

DNA/GO functional structures have been widely used in biosensors, biomedicine and materials science. However, most studies about DNA/GO functional structures do not take into account the coexistence of both large unoxidized and oxidized regions on GO sheets. This special local structure provides the boundary region, which is the junction area between unoxidized and oxidized regions, and exhibits a special amphiphilic property of the GO sheets. Here based on molecular dynamics simulations, our results predict that the adsorption efficiency of long strand ssDNA molecules adsorbed on GO is 43%. Further analysis has shown that the ssDNA adsorption behaviors on the GO surface are more likely to start in the boundary region, even for 20 mer ssDNA molecules. Looking into the adsorption dynamic process we can see that the hydrogen bonds between ssDNA and GO are very active and easily broken and formed, especially for the boundary region of the GO surface, resulting in easy capture and adsorption of the ssDNA molecules on this region. The result provides insightful understanding of the adsorption behavior of ssDNA molecules on this amphiphilic GO surface and is helpful in the design of DNA/GO functional structure-based biosensors.

中文翻译：

ssDNA吸附在氧化石墨烯上的长度特征，氧化石墨烯具有较大的未氧化和氧化区域

DNA / GO功能结构已广泛用于生物传感器，生物医学和材料科学中。但是，大多数有关DNA / GO功能结构的研究都没有考虑到GO板上大的未氧化区域和氧化区域的共存。这种特殊的局部结构提供了边界区域，该边界区域是未氧化区域和氧化区域之间的接合区域，并且具有GO片材的特殊两亲特性。在此基于分子动力学模拟，我们的结果预测长链单链DNA分子在GO上的吸附效率为43％。进一步的分析表明，即使对于20 mer ssDNA分子，GO表面上的ssDNA吸附行为也更有可能在边界区域开始。观察吸附动力学过程，我们发现ssDNA和GO之间的氢键非常活跃，容易断裂和形成，特别是在GO表面的边界区域，从而使ssDNA分子易于捕获和吸附。该结果提供了对ssDNA分子在该两亲GO表面上的吸附行为的深刻理解，并有助于设计基于DNA / GO功能结构的生物传感器。

更新日期：2020-03-27

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