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In vitro and in vivo effects of concentrated growth factor on cells and tissues.
Journal of Biomedical Materials Research Part A ( IF 3.9 ) Pub Date : 2020-02-28 , DOI: 10.1002/jbm.a.36906
Fahimeh Tabatabaei 1, 2 , Zahra Aghamohammadi 1 , Lobat Tayebi 2
Affiliation  

This article reviews the biological outcome of the concentrated growth factor (CGF), a new platelet derivative used for tissue regeneration, in published articles related to the use of this product in basic and clinical studies. An electronic literature research using PubMed and SCOPUS was performed using combination of keywords: “concentrated growth factor” (OR “CGF”), AND “stem cells,” AND “cells” OR “cell proliferation” OR “cell migration” OR “cell differentiation,” AND “repair” OR “survival” OR “revitalization,” AND “tissue” OR “bone.” Forty‐five articles that were published between 2012 and 2020 met the inclusion criteria. These studies have used CGF as fresh solid form, freeze‐dried, membrane, extract, or exudate. Most studies demonstrate the positive effects of CGF in a dose‐dependent manner under certain concentrations. Studies comparing CGF with other platelet concentrates, report lower efficiency, no statistically significant differences, or better results for CGF. Combination of CGF with stem cells and biomaterials significantly improves bone regeneration and the effect of allograft or collagen membrane is better than CGF alone. For a better examination of the biological outcomes of CGF, the standardization of CGF preparation regarding the choice of the test tube material for blood collection, the required volume of blood, the necessary count of platelets in CGF, and the most appropriate type of CGF are recommended.

中文翻译:

浓缩生长因子对细胞和组织的体外和体内影响。

本文回顾了浓缩生长因子 (CGF)(一种用于组织再生的新型血小板衍生物)的生物学结果,该文章发表在与该产品在基础和临床研究中的使用相关的文章中。使用 PubMed 和 SCOPUS 的电子文献研究是使用以下关键词组合进行的:“浓缩生长因子”(或“CGF”)、“干细胞”、“细胞”或“细胞增殖”或“细胞迁移”或“细胞”分化”、“修复”或“生存”或“恢复活力”、“组织”或“骨骼”。2012 年至 2020 年间发表的 45 篇文章符合纳入标准。这些研究使用 CGF 作为新鲜固体形式、冷冻干燥、膜、提取物或渗出物。大多数研究证明 CGF 在某些浓度下以剂量依赖性方式产生积极影响。将 CGF 与其他血小板浓缩物进行比较的研究报告说,CGF 的效率较低,没有统计学上的显着差异,或者结果更好。CGF与干细胞和生物材料的结合显着促进骨再生,同种异体移植或胶原膜的效果优于单独使用CGF。为了更好地检查 CGF 的生物学结果,CGF 制剂的标准化关于采血试管材料的选择、所需的血液量、CGF 中所需的血小板计数以及最合适的 CGF 类型是受到推崇的。CGF与干细胞和生物材料的结合显着促进骨再生,同种异体移植或胶原膜的效果优于单独使用CGF。为了更好地检查 CGF 的生物学结果,CGF 制剂的标准化关于采血试管材料的选择、所需的血液量、CGF 中所需的血小板计数以及最合适的 CGF 类型是受到推崇的。CGF与干细胞和生物材料的结合显着促进骨再生,同种异体移植或胶原膜的效果优于单独使用CGF。为了更好地检查 CGF 的生物学结果,CGF 制剂的标准化关于采血试管材料的选择、所需的血液量、CGF 中所需的血小板计数以及最合适的 CGF 类型是受到推崇的。
更新日期:2020-02-28
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