Facial nerves are frequently crushed or cut during facial surgery. In this study, the feasibility of repairing facial nerves in rabbits after crush or cut off injury was evaluated using collagen conduits with A collagen‐binding domain (CBD)‐human basic fibroblast growth factor (bFGF). A total of 39 six‐month‐old New Zealand White rabbits were randomly divided into four groups of nine rabbits, and bilateral crush or cut off injuries were made on each animal's face. Three rabbits were classified as the healthy control. The facial nerves were cut or crushed and then were either untreated or wrapped with a collagen conduit plus bFGF. At the 15, 30, and 90 days after the injury, three rabbits in each group were sacrificed. Regeneration of the injured facial nerve was evaluated using electrophysiological examination (compound muscle action potentials, CAMPs), scanning electron microscopy, and histological observation. The results suggested that using collagen conduits with recombinant proteins CBD‐bFGF to repair facial nerves with crush or cut off injuries promoted functional facial nerve recovery. This treatment, as a possible therapeutic for patients with facial nerve injury, requires further investigation.

中文翻译：

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胶原加碱性成纤维细胞生长因子修复兔面神经挤压伤[J].

面部神经在面部手术过程中经常被压碎或切断。在这项研究中，使用具有胶原结合域 (CBD)-人碱性成纤维细胞生长因子 (bFGF) 的胶原导管评估了修复兔挤压或切断损伤后面神经的可行性。将 39 只 6 个月大的新西兰白兔随机分为四组，每组 9 只，对每只动物的面部进行双侧挤压或切断伤。三只兔子被归类为健康对照。面部神经被切断或压碎，然后未经处理或用胶原导管加 bFGF 包裹。伤后15、30、90天，每组处死3只兔。使用电生理检查（复合肌肉动作电位，CAMPs）、扫描电子显微镜和组织学观察评估受损面神经的再生情况。结果表明，使用含有重组蛋白 CBD-bFGF 的胶原导管修复挤压或切断损伤的面神经可促进功能性面神经恢复。这种治疗作为面神经损伤患者的一种可能治疗方法，需要进一步研究。