Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation,European Journal of Organic Chemistry

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Solid Phase Synthesis of Sulfonimidamide Pseudopeptides and Library Generation
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-02-24 , DOI: 10.1002/ejoc.202000108
Praveen K. Chinthakindi ₁ , Andrea Benediktsdottir ₁ , Per I. Arvidsson _{2,

3} , Yantao Chen ₄ , Anja Sandström ₁

Affiliation

In this work the sulfonimidamide functionality has been combined with peptides forming sulfonimidamide pseudopeptides as potential new modalities in drug discovery. Three alternative synthetic methods to generate the pseudopeptides have been developed, all harmonized with classical solid‐phase peptide synthesis (SPPS), including both on‐ and off‐resin sulfonimidamide synthesis. The methods allow late stage modifications and parallel syntheses.

中文翻译：

磺酰亚胺酰胺类多肽肽的固相合成和文库生成

在这项工作中，磺酰亚胺酰胺功能已与形成磺酰胺酰胺假肽的肽结合在一起，成为药物发现中潜在的新形式。已经开发了三种产生假肽的替代合成方法，所有这些方法均与经典固相肽合成（SPPS）相协调，包括树脂上和树脂外的磺酰亚胺酰胺的合成。该方法允许后期修改和并行合成。

更新日期：2020-02-24

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