An ideal animal model is a prerequisite for the basic research of uterus transplantation. This study aimed to develop a new cervical ectopic uterus transplantation mice model, which was established by vascular anastomosis of the right common iliac artery and vein of the donor with the right common carotid artery and external jugular vein of the recipient, respectively, using the cuff method. The survival status of the transplanted uterus was assessed by macroscopic observation and histological examination after surgery, and the function of the graft uterus was tested by verifying whether the pregnancy is possible. A total of 40 transplants were performed, of which only 1 failed due to donor hemorrhage. After 26 transplants, the total operation time reduced to 52.4 ± 3.8 minutes, of which the total ischemia time took 6.6 ± 1.1 minutes. Sixty days after transplantation, all the graft uteri had a good blood supply and spontaneous contraction. The histology showed no significant difference between the transplanted uterus and the native. Embryo transfer experiments have proven that the transplanted uterus has uterine function. In conclusion, this new model is an effective and simple mice model for the studies of the scientific issues related to uterus transplantation.

中文翻译：

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小鼠宫颈异位子宫移植后活产。

理想的动物模型是子宫移植基础研究的前提。本研究旨在建立一种新的宫颈异位子宫移植小鼠模型，该模型是通过将供者的右髂总动、静脉分别与受者的右颈总动脉和颈外静脉进行血管吻合，使用袖带建立的。方法。术后通过肉眼观察和组织学检查评估移植子宫的存活情况，并通过验证能否妊娠来检测移植子宫的功能。共进行了 40 例移植手术，其中仅 1 例因供体出血而失败。26次移植后，总手术时间缩短为52.4±3.8分钟，其中总缺血时间为6.6±1.1分钟。移植后60天，所有移植子宫血供良好，可自发收缩。组织学显示移植子宫和天然子宫之间没有显着差异。胚胎移植实验证明，移植的子宫具有子宫功能。总之，这种新模型是一种有效且简单的小鼠模型，可用于研究与子宫移植相关的科学问题。