Abstract Cancer is one of the major life threatening diseases, with higher mortality rate and morbidity. It is always a challenge for effective drug delivery and release of drug in specific tumor sites. Therefore to identify the synergistic effect of chemotherapeutic drug and photo thermal agent on tumor area, Doxorubicin (DOX) acts as anticancer agent but it has low aqueous solubility so its clinical application is limited. The present study developed doxorubicin (DOX) were designed to be with the poly ethylene glycol (PEG) functionalized copper and selenium (Cu-Se) nanoparticles (PEG@Cu-Se+DOX) and it is efficiently synthesized and enhance its aqueous formulation and improve the prostate cancer (DU145 and LNCaP) activity. The characteristics like mono dispersity, size stability and constant spectral of as-synthesized nanoparticles are comparably excellent than DOX alone. Also the enhanced cellular uptake and in vitro cytoxicicty suggests these nanoparticles selectively killing prostate cancer. In this present study explained that PEG@Cu-Se+DOX as a safe and hopeful strategy for chemotherapeutics of photothermal therapy and deserve for further clinical evaluations.

中文翻译：

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负载DOX的PEG包覆Cu@Se纳米杂化囊泡提高前列腺癌光热治疗和护理的治疗效率

摘要 癌症是威胁生命的主要疾病之一，死亡率和发病率较高。在特定肿瘤部位进行有效的药物递送和药物释放一直是一个挑战。因此，为了确定化疗药物和光热剂对肿瘤区域的协同作用，多柔比星（DOX）作为抗癌剂，但其水溶性低，因此其临床应用受到限制。本研究开发的多柔比星 (DOX) 被设计为与聚乙二醇 (PEG) 功能化的铜和硒 (Cu-Se) 纳米粒子 (PEG@Cu-Se+DOX) 一起使用，它可以有效合成并增强其水性配方和改善前列腺癌（DU145 和 LNCaP）活性。具有单分散性、合成纳米粒子的尺寸稳定性和恒定光谱比单独的 DOX 更出色。此外，增强的细胞摄取和体外细胞毒性表明这些纳米颗粒可以选择性地杀死前列腺癌。在本研究中，PEG@Cu-Se+DOX 是一种安全且有希望的光热疗法化疗策略，值得进一步临床评估。