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A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Detects Biological Targets
Chem ( IF 19.1 ) Pub Date : 2020-02-24 , DOI: 10.1016/j.chempr.2020.01.023
Xianglong Zhu , Xiaoxue Tang , Hongyu Lin , Saige Shi , Hehe Xiong , Qiuju Zhou , Ao Li , Qiaoyang Wang , Xiaoyuan Chen , Jinhao Gao

19F magnetic resonance imaging (19F MRI) is a promising technique for in vivo molecular imaging and clinical diagnosis, benefiting from its negligible background and unlimited tissue penetration depth. However, the development of 19F probes with good water solubility and versatile functions for bioresponsive and practical applications remains a challenge. Here, we report fluorinated ion liquids (ILs) as a new type of fluorine agents and build a fluorinated ionic liquid-based activatable 19F MRI platform (FILAMP), which relies on the phase transition of ILs. Upon exposure to environmental stimulation, coating polymer dissolves or degrades to release the fluorinated ILs payload, which rapidly enhances 19F signal. This “turn-on” response is verified by the successful detection of biological targets (for example, dysregulated pH and MMP overexpression) at the cellular level and in mice, demonstrating the potential of FILAMP as a robust activatable 19F probe for diagnosis and monitoring of biological and pathological processes.



中文翻译:

基于氟化离子液体的可激活19 F MRI平台可检测生物目标

19 F磁共振成像(19 F MRI)受益于其可忽略的背景和无限的组织穿透深度,是一种用于体内分子成像和临床诊断的有前途的技术。然而,开发具有良好水溶性和多功能功能的19 F探针以用于生物响应和实际应用仍然是一个挑战。在这里,我们报告氟化离子液体(ILs)作为一种新型的氟剂,并建立一个基于ILs相变的基于氟化离子液体的可激活19 F MRI平台(FILAMP)。暴露于环境刺激下,涂料聚合物溶解或降解以释放氟化的ILs有效负载,从而迅速提高19F信号。通过在细胞水平和小鼠中成功检测到生物学目标(例如,失调的pH和MMP过表达),验证了这种“开启”响应,证明了FILAMP作为一种强大的可激活的19 F探针进行诊断和监测的潜力生物和病理过程。

更新日期:2020-02-24
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