OBJECTIVE Chronic pain is a prevalent condition which has a significant effect on the lives of those it impacts. High-frequency 10 kHz spinal cord stimulation (10 kHz SCS) has been shown to provide paresthesia-free pain relief for a wide variety of pain indications. This article summarizes the current and emerging data as they relate to the clinical use of the therapy in various pain syndromes. METHODS A literature search was conducted using the PubMed electronic database using keywords related to 10 kHz SCS. The database was queried from 2013 to May 2019. Articles reporting clinical studies that included human subjects permanently treated with 10 kHz SCS (Senza® system) were included in the review. Recent and relevant conference proceedings known to the authors were also included. RESULTS The selected literature demonstrated significant evidence for the efficacy of 10 kHz SCS in treating chronic back and leg pain (CBLP), including a randomized, controlled trial as well as prospective and retrospective studies. One-year follow-up responder rates (pain relief ≥50%) ranged from 60% to 80%. Other studies and case series showed promising outcomes in specific conditions, including nonsurgical refractory back pain, neuropathic limb pain, complex regional pain syndrome, chronic widespread pain, chronic pelvic pain, and intractable headache. Subgroup analyses also pointed toward the potential of 10 kHz SCS being successful when low-frequency SCS has failed. The vast majority of these studies reported improved quality of life (QOL) metrics and/or reduced opioid consumption. CONCLUSIONS Level I evidence already exists for the efficacy of 10 kHz SCS in treating CBLP, supported by real-world clinical experience. Other studies demonstrate the potential of the therapy across a range of chronic pain etiologies, although larger confirmatory studies are recommended. Overall, the literature suggests that the therapy is associated with improved QOL as well as reduced opioid consumption.

中文翻译：

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10 kHz SCS疗法可缓解疼痛并改善生活质量：临床证据摘要。

目的慢性疼痛是一种普遍的疾病，对它所影响的人们的生活有重大影响。高频10 kHz脊髓刺激（10 kHz SCS）已显示可为多种疼痛适应症提供无感觉异常的疼痛缓解。本文总结了当前和新兴的数据，这些数据与该疗法在各种疼痛综合征中的临床应用有关。方法使用PubMed电子数据库使用与10 kHz SCS相关的关键字进行文献检索。该数据库是从2013年至2019年5月查询的。评价中包括报告临床研究的文章，其中包括接受10 kHz SCS（Senza®系统）永久治疗的人类受试者。作者还了解了最新的和相关的会议记录。结果选定的文献证明了10 kHz SCS在治疗慢性背痛和腿痛（CBLP）中的有效性的重要证据，包括一项随机对照试验以及前瞻性和回顾性研究。一年的随访缓解率（疼痛缓解≥50％）为60％至80％。其他研究和病例系列研究表明，在特定情况下有希望的结果，包括非手术难治性背痛，神经性肢体疼痛，复杂的局部疼痛综合征，慢性广泛性疼痛，慢性骨盆痛和顽固性头痛。子组分析还指出，当低频SCS发生故障时，10 kHz SCS可能会成功。这些研究中的绝大多数报告了改善的生活质量（QOL）指标和/或减少了阿片类药物的消费。结论在现实世界的临床经验的支持下，I级证据已经证明10 kHz SCS在治疗CBLP中的功效。其他研究证明了该疗法在一系列慢性疼痛病因学方面的潜力，尽管建议进行更大的确认性研究。总体而言，文献表明该疗法与改善的QOL以及减少阿片类药物的消耗有关。