Today, we are witnessing a revolution in the treatment of cancer using immunotherapy. In the past decade, work from many laboratories and clinicians has unequivocally demonstrated that the immune system can eradicate established cancers and enhance patient survival. However, immunotherapies have distinct tumor response-to-toxicity profiles owing to distinct mechanisms of action. We have previously termed immunotherapies that activate a general systemic immune response as enhancement cancer immunotherapy and those that target a specific dysfunctional immune response, especially within the tumor microenvironment, as normalization cancer immunotherapy. In this perspective, we provide a framework for normalization cancer immunotherapy in the context of melanoma.

中文翻译：

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黑色素瘤的标准化癌症免疫疗法。

今天，我们正在目睹使用免疫疗法治疗癌症的一场革命。在过去十年中，许多实验室和临床医生的工作明确表明，免疫系统可以根除已建立的癌症并提高患者的存活率。然而，由于不同的作用机制，免疫疗法具有不同的肿瘤对毒性反应特征。我们之前将激活全身免疫反应的免疫疗法称为增强型癌症免疫疗法，将靶向特定功能失调的免疫反应，尤其是在肿瘤微环境中的免疫疗法称为正常化癌症免疫疗法。从这个角度来看，我们为黑色素瘤背景下的正常化癌症免疫治疗提供了一个框架。