Renal course and clinical outcomes in pregnant women with primary membranous nephropathy are not completely understood. In addition, the use of autoantibodies to M-type phospholipase A₂ receptor (PLA₂R) as a serologic marker throughout pregnancy and postpartum in the mother and baby is not yet fully elucidated. We followed up a pregnant woman with primary membranous nephropathy during pregnancy and postpartum and describe the clinical course and outcomes of mother and baby and the course of PLA₂R antibody titers. We show evidence of transplacental transfer of PLA₂R antibody from mother to fetus. In addition, we observe the effect of breastfeeding in a PLA₂R antibody–positive pregnancy and describe the transfer of this antibody into breast milk. Although pregnancy in women with underlying PLA₂R antibody–positive membranous nephropathy is possible, there is an increase in risk to both mother and fetus, requiring a multidisciplinary team approach and careful monitoring of both neonate and mother during pregnancy and postpartum.

原发性膜性肾病孕妇的肾脏病程和临床结局尚未完全了解。另外，使用自身抗体以M型磷脂酶A ₂受体（PLA ₂ R）贯穿在母亲在怀孕和产后和婴儿血清学标志物还没有被完全阐明。我们追踪了一名孕妇在怀孕和产后发生原发性膜性肾病的情况，并描述了母婴的临床病程和预后以及PLA ₂ R抗体滴度的病程。我们显示了从母亲到胎儿的PLA ₂ R抗体经胎盘转移的证据。此外，我们观察了PLA ₂中母乳喂养的效果R抗体阳性妊娠，并描述了该抗体向母乳中的转移。尽管具有潜在PLA ₂ R抗体阳性的膜性肾病的妇女有可能怀孕，但母亲和胎儿的风险均增加，因此需要多学科团队合作的方法，并在妊娠和产后对新生儿和母亲进行仔细监测。