The delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human cells. Here, we report on an investigation of a series of nanoparticles formed with various poly cationic peptides that can release nucleic acids in response to a mitochondrial environment. A significant relationship was found between the number of and the location of arginine and histidine residues in the peptide sequence and the release of nucleic acids in a mitochondrial environment.

中文翻译：

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响应线粒体环境而释放核酸的纳米颗粒的开发

靶向突变 mtDNA 的核酸的递送代表了解决各种线粒体相关疾病的潜在策略。我们之前开发了一种 MITO-Porter，一种能够将核酸纳米颗粒输送到人体细胞线粒体的纳米载体。在这里，我们报告了一系列由各种聚阳离子肽形成的纳米颗粒的研究，这些聚阳离子肽可以响应线粒体环境释放核酸。发现肽序列中精氨酸和组氨酸残基的数量和位置与线粒体环境中核酸的释放之间存在显着关系。