BACKGROUND In recent years, some studies have shown that there is a positive association between the number of oocytes retrieved and the cumulative live birth rate (CLBR) after fresh and frozen cycles of one oocyte retrieval. However, almost no studies have examined the association between the number of oocytes retrieved and the CLBR when using the "freeze-all" strategy. We performed this study to investigate the effects of an extreme oocyte yield during the first "freeze-all" cycle on the cumulative live birth rate among patients younger than 35 years old. METHODS This was a retrospective cohort study performed in a university-affiliated reproductive medicine centre. Data obtained from 3276 women aged younger than 35 years who underwent their first "freeze-all" cycle (IVF/ICSI) were collected between January 2009 and December 2016. In all, 5025 frozen cycles took place during the follow-up period from January 2009 to December 2018. Patients were divided into five groups according to oocytes retrieved (group 1: 4-10 oocytes; group 2: 11-20 oocytes; group 3: 21-30 oocytes; group 4: 31-40 oocytes; group 5: > 40 oocytes). The primary outcome was the cumulative live birth rate. RESULTS Unadjusted results showed that the cumulative live birth rate significantly increased as the number of oocytes retrieved increased and reached up to 93.82% in cases with yields of 21-30 oocytes (P < 0.05), after which it did not have a significant increase (P > 0.05). After adjusting for confounders, our results showed that the number of oocytes retrieved is an independent positive predictor of cumulative live birth rate when using a "freeze-all" strategy. (P < 0.001). In addition, the fertilization rate and the gonadotropin dose also influenced the cumulative live birth rate (P<0.05). CONCLUSIONS Among women younger than 35 years old who underwent the "freeze-all" strategy, the number of oocytes retrieved positively correlated with the cumulative live birth rate. Taking both efficacy and safety into account, ovarian stimulation should be rational, and the upper limit of the oocyte yield should be no more than 30.

中文翻译：

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根据“全部冻结”策略获取的卵母细胞数量的累计活产率。

背景技术近年来，一些研究表明，在一次和一次卵子取回的新鲜和冷冻周期后，取回的卵母细胞的数量与累积活产率（CLBR）之间存在正相关。但是，几乎没有研究检查使用“全部冻结”策略时回收的卵母细胞数量与CLBR之间的关系。我们进行了这项研究，以调查在第一个“全冻”周期中卵母细胞极高产量对35岁以下患者的累计活产率的影响。方法这是一项在大学附属生殖医学中心进行的回顾性队列研究。从3276名年龄小于35岁的女性中进行首次冷冻试验的数据 周期（IVF / ICSI）在2009年1月至2016年12月期间收集。在2009年1月至2018年12月的随访期间共进行了5025例冷冻周期。根据检索到的卵母细胞将患者分为五组（第1组： 4-10个卵母细胞;第2组：11-20个卵母细胞;第3组：21-30个卵母细胞;第4组：31-40个卵母细胞;第5组：> 40个卵母细胞。主要结果是累计活产率。结果未经调整的结果显示，随着卵母细胞数量的增加，累计活产率显着增加，在21-30个卵母细胞产量的情况下，卵母细胞的累计出生率达到93.82％（P <0.05），之后没有显着增加（ P> 0.05）。在调整了混杂因素之后，我们的结果表明，使用“全部冷冻”策略时，回收的卵母细胞数量是累积活产率的独立阳性预测因子。（P <0.001）。此外，受精率和促性腺激素剂量也影响累计活产率（P <0.05）。结论在接受“全部冻结”策略的35岁以下女性中，回收的卵母细胞数量与活产累积率呈正相关。考虑到疗效和安全性，应该合理地刺激卵巢，卵母细胞产量的上限应不超过30。结论在接受“全部冻结”策略的35岁以下女性中，回收的卵母细胞数量与活产累积率呈正相关。考虑到疗效和安全性，应该合理地刺激卵巢，卵母细胞产量的上限应不超过30。结论在接受“全部冻结”策略的35岁以下女性中，回收的卵母细胞数量与活产累积率呈正相关。考虑到疗效和安全性，应该合理地刺激卵巢，卵母细胞产量的上限应不超过30。