Poly(ethylene glycol) (PEG), known for its biocompatibility and biodegradability, has been in use for surface coating of nanoparticles. PEG coating prevents opsonization, thereby enhancing the systemic circulation time of nanoparticles. It is nonfluorescent in nature requiring additional conjugation with fluorescent dye molecules for tracking the nanoparticles. In the current work, PEG was converted into fluorescent PEG (FL PEG) through a facile one-pot synthesis approach. This eliminates the need for additional fluorescent tag for tracking the nanoparticles. FL PEG showed excellent biocompatibility with normal cell lines (L929). There was a delayed uptake of FL PEG by zebrafish embryos which indicated the systemic circulation enhancement property of PEG. Fluorescent polymer encapsulated metal nanoparticles (PoeM NPs) were prepared by using FL PEG as a coating agent. The antibacterial and photothermal therapy by PoeM NPs were demonstrated. PoeM (Ag) NPs showed a significant antibacterial effect equivalent to that of gentamicin (broad spectrum antibiotic). PoeM (Au) nanoshells (NS) were prepared by galvanic replacement of PoeM (Ag) NPs. They were further used for photothermal therapy of cancer cells. They showed 67 ± 0.5% of cancer cell death when subjected to NIR laser irradiation. Thus, FL PEG based PoeM NPs could lead to the development of multifunctional nanosystems to be deployed for both imaging and therapeutic applications.

中文翻译：

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用于成像和治疗应用的荧光聚合物包封的金属（PoeM）纳米粒子的简便合成

以生物相容性和生物降解性而闻名的聚乙二醇（PEG）已用于纳米粒子的表面涂层。PEG涂层可防止调理作用，从而延长纳米颗粒的全身循环时间。它本质上是非荧光的，需要与荧光染料分子进行额外的缀合以追踪纳米粒子。在当前的工作中，通过一种简便的一锅合成方法将PEG转化为荧光PEG（FL PEG）。这消除了用于跟踪纳米粒子的额外荧光标签的需求。FL PEG与正常细胞系（L929）表现出出色的生物相容性。斑马鱼胚胎延迟摄取FL PEG，这表明PEG具有增强全身循环的特性。通过使用FL PEG作为涂层剂制备了荧光聚合物封装的金属纳米颗粒（PoeM NPs）。证明了PoeM NP的抗菌和光热疗法。PoeM（Ag）NPs具有与庆大霉素（广谱抗生素）相当的显着抗菌作用。PoeM（Au）纳米壳（NS）是通过电动替换PoeM（Ag）NP制备的。它们进一步用于癌细胞的光热疗法。当进行近红外激光照射时，他们显示出67±0.5％的癌细胞死亡。因此，基于FL PEG的PoeM NP可以导致开发多功能纳米系统，以用于成像和治疗应用。PoeM（Ag）NPs具有与庆大霉素（广谱抗生素）相当的显着抗菌作用。PoeM（Au）纳米壳（NS）是通过电动替换PoeM（Ag）NP制备的。它们进一步用于癌细胞的光热疗法。当进行近红外激光照射时，他们显示出67±0.5％的癌细胞死亡。因此，基于FL PEG的PoeM NP可以导致开发多功能纳米系统，以用于成像和治疗应用。PoeM（Ag）NPs具有与庆大霉素（广谱抗生素）相当的显着抗菌作用。PoeM（Au）纳米壳（NS）是通过电动替换PoeM（Ag）NP制备的。它们进一步用于癌细胞的光热疗法。当进行近红外激光照射时，他们显示出67±0.5％的癌细胞死亡。因此，基于FL PEG的PoeM NP可以导致开发多功能纳米系统，以用于成像和治疗应用。