Recent Advances in Catalytic Dearomative Hydroboration of N‐Heteroarenes,ChemCatChem

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Recent Advances in Catalytic Dearomative Hydroboration of N‐Heteroarenes
ChemCatChem ( IF 3.8 ) Pub Date : 2020-02-21 , DOI: 10.1002/cctc.201902303
Sehoon Park _{1,

2}

Affiliation

Catalytic dearomative reduction of N‐heteroarenes is of important transformations in organic synthesis as well as medicinal chemistry, since the reduced aza compounds such as dihydropyridines can be synthetic building blocks as well as structural motifs for bioactive natural products and pharmaceuticals. While hydrogenation and hydrosilylation are well‐utilized methods for such dearomative reduction of N‐heteroarenes, the dearomative hydroboration has recently emerged as a competent alternative with high selectivity and good functional group tolerance. This Minireview describes recent advances in the catalytic hydroboration of N‐heteroarenes. A diverse range of new catalytic systems will be detailed with strong emphasis on their unique working modes, which are closely related to chemo‐, regio‐ and stereooutcomes observed in the hydroboration of N‐heteroarenes.

中文翻译：

N-杂芳烃催化脱氢硼氢化反应的最新进展

N-杂芳烃的催化脱芳香化还原是有机合成以及药物化学领域的重要转变，因为还原的氮杂化合物（如二氢吡啶）可以作为合成基石以及生物活性天然产物和药物的结构基序。尽管氢化和氢化硅烷化是用于脱芳基还原N-杂芳烃的良好方法，但脱芳基硼氢化最近已成为具有高选择性和良好官能团耐受性的有效替代方法。此Minireview描述了N-杂芳烃催化加氢硼化的最新进展。将详细介绍各种新的催化体系，并重点强调其独特的工作模式，这些模式与在N-杂芳烃的硼氢化反应中观察到的化学，区域和立体结果密切相关。

更新日期：2020-02-21

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