Summary

This retrospective study investigated the incidence of fracture in 4420 type 1 diabetes (T1DM) patients. Our findings indicate that patients with T1DM have an increased incidence of fractures. Further studies and preventive measures are urgently needed.

Introduction

The aim of this study was to investigate the incidence of fracture in patients with type 1 diabetes mellitus (T1DM).

Methods

This study is based on the German Disease Analyzer database and included 4258 adult individuals with a T1DM diagnosis documented between January 2000 and December 2015 in 1203 general practices in Germany. Individual matching of T1DM and non-diabetic patients was performed. The cumulative incidence of new fractures was shown for up to 10 years after the index date using Kaplan-Meier curves. Cox proportional hazard models (dependent variable: incident fracture) were used to estimate the effect of T1DM on fracture incidence, as well as the effect of predefined variables on fracture incidence.

Results

After 10 years of follow-up, the cumulative fracture incidence was 18.4% for T1DM patients and 9.9% for non-diabetic patients (p < 0.001). A strong association between T1DM and fractures was found (HR, 2.01 (95% CI, 1.70–2.38) p < 0.001) in both female and male patients. Significant differences between T1DM and non-diabetes patients were found in lower leg/ankle, foot and toe, shoulder/upper arm, and rib(s), sternum and thoracic spine fractures. A significant association between higher age and fracture incidence was observed in T1DM patients.

Conclusions

In summary, we found that patients with T1DM have a twofold increased fracture rate compared with healthy controls. Furthermore, fractures were associated with increased age and high HbA1c values.

中文翻译：

---

1型糖尿病患者的骨折发生率—对4420位患者的回顾性研究

概要

这项回顾性研究调查了4420型1型糖尿病（T1DM）患者的骨折发生率。我们的发现表明，T1DM患者的骨折发生率增加。迫切需要进一步的研究和预防措施。

介绍

这项研究的目的是调查1型糖尿病（T1DM）患者的骨折发生率。

方法

这项研究基于德国疾病分析器数据库，纳入了4258名2000年1月至2015年12月之间在德国1203例常规实践中诊断为T1DM的成年个体。对T1DM和非糖尿病患者进行个体匹配。使用Kaplan-Meier曲线显示新的骨折的累积发生率在索引日期后长达10年。使用Cox比例风险模型（因变量：入射骨折）来评估T1DM对骨折发生率的影响以及预定义变量对骨折发生率的影响。

结果

经过10年的随访，T1DM患者的累积骨折发生率为18.4％，非糖尿病患者为9.9％（p  <0.001）。 在女性和男性患者中，T1DM与骨折之间存在很强的关联（HR，2.01（95％CI，1.70–2.38），p <0.001）。T1DM与非糖尿病患者之间的显着差异在于小腿/脚踝，脚和脚趾，肩/上臂和肋骨，胸骨和胸椎骨折。在T1DM患者中观察到较高的年龄与骨折发生率之间存在显着关联。

结论

总而言之，我们发现与健康对照组相比，T1DM患者的骨折率增加了两倍。此外，骨折与年龄增加和HbA1c值升高有关。