Natural alkaloid galantamine is widely used for the treatment of Alzheimer’s disease and various other memory impairments. Galantamine hydrobromide (GH) is available as fast-release tablets, extended-release capsules, and oral solution. However, oral delivery of GH can cause side effects, such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery is one possible way to avoid such unwanted effects and is also patient friendly, especially for unconscious patients, patients with swallowing difficulties, and patients with mental disturbances. In this work, thermoresponsive copolymer networks based on poly(N-isopropylacrylamide) were studied as new platforms for potential transdermal GH delivery. Series of networks of varied structure and composition were synthesized and investigated by applying swelling kinetics and different spectroscopic and thermal methods. The network films were drug loaded in GH aqueous solution and main characteristics of the obtained GH delivery systems were evaluated. The GH release kinetic profiles in BS at 37 °C were established and discussed.

中文翻译：

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用于加兰他敏氢溴酸盐递送的热响应聚（N-异丙基丙烯酰胺）共聚物网络

天然生物碱加兰他敏广泛用于治疗阿尔茨海默病和其他各种记忆障碍。氢溴酸加兰他敏 (GH) 有速释片剂、缓释胶囊和口服溶液。然而，口服GH会引起副作用，如恶心、呕吐和胃肠道紊乱。透皮给药是避免此类不良反应的一种可能方式，并且对患者友好，尤其是对于昏迷患者、吞咽困难患者和精神障碍患者。在这项工作中，研究了基于聚（N-异丙基丙烯酰胺）的热响应共聚物网络作为潜在透皮 GH 递送的新平台。通过应用溶胀动力学和不同的光谱和热方法合成和研究了一系列不同结构和组成的网络。网络膜在 GH 水溶液中载药, 并评估了所获得的 GH 递送系统的主要特性。建立并讨论了 37 °C 下 BS 中的 GH 释放动力学曲线。