As an advanced structural material, DNA has been widely exploited to construct a variety of elegant but powerful DNA geometric polyhedrons (DNA-GPs). The high programmability, good biocompatibility and diverse functionalization approaches, combined with stable frames and hollow interiors, have conferred vast opportunities in multiple interdisciplinary research. Herein, we one by one review recent progress in the assembly strategy studies of different DNA-GPs. Moreover, many applications are highlighted to elucidate the development in biosensing and drug delivery, and explore great potentials for frame-based organization, dynamic DNA devices, as well as cargo encapsulation and controlled release.

作为一种先进的结构材料，DNA已被广泛用于构建各种优雅而强大的DNA几何多面体（DNA-GPs）。高度的可编程性，良好的生物相容性和多种功能化方法，再加上稳定的框架和中空的内部结构，为跨学科研究提供了广阔的机遇。在此，我们一个接一个地回顾了不同DNA-GP的组装策略研究的最新进展。此外，重点突出了许多应用，以阐明生物传感和药物输送的发展，并探索基于框架的组织，动态DNA装置以及货物封装和控释的巨大潜力。