The pathological and immunohistochemical (IHC) findings associated with infection due to canine morbilivírus (canine distemper virus, CDV) are described in coatis (Nasua nasua). Tissue fragments of coatis (n = 13) that died at the Bela Vista Sanctuary, Paraná, Southern Brazil, were routinely processed for histopathology to identify the main histopathologic patterns as compared to that of the domestic dog. Selected formalin-fixed paraffin-embedded (FFPE) tissue fragments of the lungs, liver, urinary bladder and small intestine were used in IHC assays designed to identify the antigens of CDV, canine adenovirus (CAdV-1 and CAdV-2) and canine parvovirus type 2 (CPV-2). The main histopathologic patterns identified were interstitial pneumonia (n = 9), interstitial nephritis (n = 6), atrophic enteritis (n = 4) and ballooning degeneration of the uroepithelium (n = 3). Positive immunolabelling for intralesional antigens of CDV was identified in the lung with interstitial pneumonia (n = 3), in the intestine (n = 2) and in the degenerated epithelium of the urinary bladder (n = 2). Antigens of CPV-2, CAdV-1 and CAdV-2 were not identified in any FFPE tissue sections evaluated. These findings indicate that these wild carnivores were infected by a viral disease pathogen common to the domestic dog and develop similar histopathologic findings. Collectively, these findings suggest that these coatis were infected by CDV and can serve as a potential host for this infectious disease pathogen.

中文翻译：

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来自巴西南部的柯伊斯犬（Nasua nasua）感染犬瘟病毒（犬瘟热）的免疫组织化学证据。

柯伊斯犬（Nasua nasua）中描述了与因犬瘟热（犬瘟热病毒，CDV）引起的感染相关的病理和免疫组化（IHC）发现。定期处理巴西南部巴拉那州贝拉维斯塔保护区死的大肠组织碎片（n = 13），以进行组织病理学检查，以确定与家犬相比的主要组织病理学样式。肺，肝，膀胱和小肠经福尔马林固定的石蜡包埋（FFPE）组织片段用于IHC分析，旨在鉴定CDV，犬腺病毒（CAdV-1和CAdV-2）和犬细小病毒类型2（CPV-2）。确定的主要组织病理学类型为间质性肺炎（n = 9），间质性肾炎（n = 6），萎缩性肠炎（n = 4）和尿路上皮气球样变性（n = 3）。在肺间质性肺炎（n = 3），肠（n = 2）和膀胱退化的上皮细胞（n = 2）中发现了CDV病灶内抗原的阳性免疫标记。在任何评估的FFPE组织切片中均未鉴定出CPV-2，CAdV-1和CAdV-2抗原。这些发现表明，这些野生食肉动物被家犬常见的病毒性病原体感染，并形成了相似的组织病理学发现。总的来说，这些发现表明这些大衣被CDV感染，并且可以作为这种传染病病原体的潜在宿主。在肠道（n = 2）和退化的膀胱上皮（n = 2）中。在任何评估的FFPE组织切片中均未鉴定出CPV-2，CAdV-1和CAdV-2抗原。这些发现表明，这些野生食肉动物被家犬常见的病毒性病原体感染，并形成了相似的组织病理学发现。总的来说，这些发现表明这些大衣被CDV感染，并且可以作为这种传染病病原体的潜在宿主。在肠道（n = 2）和退化的膀胱上皮（n = 2）中。在任何评估的FFPE组织切片中均未鉴定出CPV-2，CAdV-1和CAdV-2抗原。这些发现表明，这些野生食肉动物被家犬常见的病毒性病原体感染，并形成了相似的组织病理学发现。总的来说，这些发现表明这些大衣被CDV感染，并且可以作为这种传染病病原体的潜在宿主。