Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index.
Leukemia ( IF 12.8 ) Pub Date : 2020-02-21 , DOI: 10.1038/s41375-020-0746-8 Fabio Efficace 1, 2 , Francesco Cottone 1 , Laura B Oswald 2 , David Cella 2 , Andrea Patriarca 3 , Pasquale Niscola 4 , Massimo Breccia 5 , Uwe Platzbecker 6 , Giuseppe A Palumbo 7 , Giovanni Caocci 8 , Reinhard Stauder 9 , Alessandra Ricco 10 , Duska Petranovic 11 , Jo Caers 12 , Mario Luppi 13 , Luana Fianchi 14 , Chiara Frairia 15 , Isabella Capodanno 16 , Elena Follini 17 , Chiara Sarlo 18 , Paola Fazi 1 , Marco Vignetti 1
Leukemia ( IF 12.8 ) Pub Date : 2020-02-21 , DOI: 10.1038/s41375-020-0746-8 Fabio Efficace 1, 2 , Francesco Cottone 1 , Laura B Oswald 2 , David Cella 2 , Andrea Patriarca 3 , Pasquale Niscola 4 , Massimo Breccia 5 , Uwe Platzbecker 6 , Giuseppe A Palumbo 7 , Giovanni Caocci 8 , Reinhard Stauder 9 , Alessandra Ricco 10 , Duska Petranovic 11 , Jo Caers 12 , Mario Luppi 13 , Luana Fianchi 14 , Chiara Frairia 15 , Isabella Capodanno 16 , Elena Follini 17 , Chiara Sarlo 18 , Paola Fazi 1 , Marco Vignetti 1
Affiliation
|
We aimed to compare fatigue of newly diagnosed patients with myelodysplastic syndromes (MDS) with that of the general population (GP). We also investigated the ability of the IPSS and IPSS-R to capture severity of patient-reported fatigue at diagnostic workup. A sample of 927 newly diagnosed patients with MDS was consecutively enrolled in a large international observational study and all patients completed the FACIT-Fatigue questionnaire at baseline. Fatigue was compared with that of the GP (N = 1075) and a 3-point difference in mean scores was considered as clinically meaningful. Fatigue of MDS patients was on average 4.6 points below the mean of the GP (95% CI, -5.9 to -3.2, p < 0.001), reflecting clinically meaningful worse fatigue. Unlike the IPSS, the IPSS-R identified clearly distinct subgroups with regard to burden of fatigue. Mean scores differences compared with GP ranged from nonclinically relevant for very low risk (Δ = -1.8, 95% CI, -4.0 to 0.5, p = 0.119) to large clinically meaningful differences for very high-risk IPSS-R patients (Δ = -8.2, 95% CI, -10.3 to -6.2, p < 0.001). At diagnostic workup, fatigue of MDS is clinically meaningful worse than that reported by the GP. Compared with the IPSS classification, the IPSS-R provides a better stratification of patients with regard to fatigue severity.
中文翻译：
与IPSS指数相比，IPSS-R更准确地捕获了新诊断的骨髓增生异常综合症患者的疲劳严重程度。
我们旨在比较新诊断为骨髓增生异常综合症（MDS）与普通人群（GP）的疲劳。我们还研究了IPSS和IPSS-R在诊断检查中捕获患者报告的疲劳严重程度的能力。连续对927名新诊断的MDS患者进行了一项国际大型观察性研究，所有患者均在基线时完成了FACIT-疲劳问卷。将疲劳与GP的疲劳进行了比较（N = 1075），平均得分的3分差异被认为具有临床意义。MDS患者的疲劳平均比GP平均值低4.6点（95％CI，-5.9至-3.2，p <0.001），反映出临床上有意义的严重疲劳。与IPSS不同，IPSS-R在疲劳负担方面明确区分了不同的亚组。与GP相比，平均得分差异从非常低风险的非临床相关性（Δ= -1.8，95％CI，-4.0到0.5，p = 0.119）到非常高的IPSS-R患者的临床意义上的巨大差异（Δ= -8.2，95％CI，-10.3至-6.2，p <0.001）。在诊断检查中，MDS的疲劳在临床上比GP报告的更为严重。与IPSS分类相比，IPSS-R在疲劳严重程度方面为患者提供了更好的分层。
更新日期：2020-02-21
中文翻译：
与IPSS指数相比，IPSS-R更准确地捕获了新诊断的骨髓增生异常综合症患者的疲劳严重程度。
我们旨在比较新诊断为骨髓增生异常综合症（MDS）与普通人群（GP）的疲劳。我们还研究了IPSS和IPSS-R在诊断检查中捕获患者报告的疲劳严重程度的能力。连续对927名新诊断的MDS患者进行了一项国际大型观察性研究，所有患者均在基线时完成了FACIT-疲劳问卷。将疲劳与GP的疲劳进行了比较（N = 1075），平均得分的3分差异被认为具有临床意义。MDS患者的疲劳平均比GP平均值低4.6点（95％CI，-5.9至-3.2，p <0.001），反映出临床上有意义的严重疲劳。与IPSS不同，IPSS-R在疲劳负担方面明确区分了不同的亚组。与GP相比，平均得分差异从非常低风险的非临床相关性（Δ= -1.8，95％CI，-4.0到0.5，p = 0.119）到非常高的IPSS-R患者的临床意义上的巨大差异（Δ= -8.2，95％CI，-10.3至-6.2，p <0.001）。在诊断检查中，MDS的疲劳在临床上比GP报告的更为严重。与IPSS分类相比，IPSS-R在疲劳严重程度方面为患者提供了更好的分层。
京公网安备 11010802027423号