Systemaic delivery of therapeutic agents to specifc sites, with a stimulus-responsive drug release profile is currently a rapidly growing area. Mesoporous silica nanoparticles (MSNs) are the useful platforms as drug/gene delivery systems due to their unique properties including the ability to control the pore size, high porosity, and morphology, which can directly affect the mechanism and profile of drug release. The appropriate fabrication strategy can tailor the particle shape and size, leading to enhanced delivery and release mechanisms. The MSN surface can be modified by using either organic or inorganic molecules to induce smart and site-specific drug delivery and release. Furthermore, application of molecules that function as pore gatekeepers with the ability to uncap via physiochemical stimuli can enhance the efficiency of drug delivery and release. This report aims to highlight the recent efforts and developments of strategies applied to render MSNs smarter and more effective for drug delivery applications.

系统性地将治疗剂系统地递送至特定部位，具有刺激响应性药物释放曲线，这是目前快速发展的领域。介孔二氧化硅纳米粒子（MSNs）具有独特的特性，包括控制孔径，高孔隙率和形态的能力，这些特性可以直接影响药物释放的机制和特性，因此是用作药物/基因传递系统的有用平台。适当的制造策略可以调整颗粒的形状和大小，从而增强输送和释放机制。可以通过使用有机或无机分子来修饰MSN表面，以诱导智能和特定部位的药物传递和释放。此外，能够通过物理化学刺激解开帽孔功能的分子的应用可以提高药物递送和释放的效率。本报告旨在重点介绍为使MSN更智能，更有效地用于药物输送应用而采取的策略的最新努力和发展。