Daytime symptoms of chronic obstructive pulmonary disease: a systematic review.,npj Primary Care Respiratory Medicine

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Daytime symptoms of chronic obstructive pulmonary disease: a systematic review.
npj Primary Care Respiratory Medicine ( IF 3.1 ) Pub Date : 2020-02-21 , DOI: 10.1038/s41533-020-0163-5
Ioanna Tsiligianni ₁ , Janwillem W H Kocks _{2,

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Affiliation

There is no single source of compiled data on symptoms experienced by patients with chronic obstructive pulmonary disease (COPD) when awake and active throughout the day. The aim of this systematic review was to evaluate the prevalence, variability, and burden (i.e., bothersomeness and/or intensity), and the impact of daytime COPD symptoms on other outcomes. The review also evaluated the impact of interventions and the measures/tools used to assess daytime COPD symptoms in patients. A systematic literature search was conducted using the primary search terms "COPD", "symptoms", and "daytime" in EMBASE®, MEDLINE®, MEDLINE® In-Process, and CENTRAL in 2016, followed by an additional search in 2018 to capture any new literature that was published since the last search. Fifty-six articles were included in the review. The accumulated evidence indicated that the symptomatic burden of COPD appears greatest in the morning, particularly upon waking, and that these morning symptoms have a substantial impact on patients' ability to function normally through the day; they also worsen quality of life. A wide variety of tools were used to evaluate symptoms across the studies. The literature also confirmed the importance of pharmacotherapy in the management of daytime COPD symptoms, and in helping normalize daily functioning. More research is needed to better understand how COPD symptoms impact daily functioning and to evaluate COPD symptoms at well-defined periods throughout the day, using validated and uniform measures/tools. This will help clinicians to better define patients' needs and take appropriate action.

中文翻译：

慢性阻塞性肺疾病的日间症状：系统评价。

关于慢性阻塞性肺病 (COPD) 患者全天清醒和活动时所经历的症状，没有单一来源的汇总数据。本系统评价的目的是评估日间慢性阻塞性肺病症状的患病率、变异性和负担（即烦扰性和/或强度）以及对其他结果的影响。该综述还评估了干预措施的影响以及用于评估患者日间慢性阻塞性肺病症状的措施/工具。2016 年，我们使用 EMBASE®、MEDLINE®、MEDLINE® In-Process 和 CENTRAL 中的主要检索词“COPD”、“症状”和“日间”进行了系统文献检索，随后于 2018 年进行了额外检索以捕获自上次检索以来发表的任何新文献。评论中纳入了 56 篇文章。积累的证据表明，慢性阻塞性肺病的症状负担在早晨最为严重，尤其是醒来时，这些早晨症状对患者全天正常运作的能力有重大影响；它们还使生活质量恶化。研究中使用了多种工具来评估症状。文献还证实了药物治疗在控制日间慢性阻塞性肺病症状和帮助日常功能正常化方面的重要性。需要更多的研究来更好地了解慢性阻塞性肺病症状如何影响日常功能，并使用经过验证的统一措施/工具在一天中明确的时间段评估慢性阻塞性肺病症状。这将有助于临床医生更好地确定患者的需求并采取适当的行动。

更新日期：2020-02-21

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