Polymeric Films for the Encapsulation, Storage, and Tunable Release of Therapeutic Microbes.,Advanced Healthcare Materials

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Polymeric Films for the Encapsulation, Storage, and Tunable Release of Therapeutic Microbes.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-02-20 , DOI: 10.1002/adhm.201901643
Kunyu Qiu ₁ , Isabella Young ₁ , Blaide M Woodburn ₂ , Yirui Huang ₁ , Aaron C Anselmo ₁

Affiliation

Microbe-based therapeutics (MBTs) are an emerging therapeutic modality for treating gastrointestinal infections and inflammatory bowel diseases. Current formulations for oral delivery of MBTs use capsules to achieve safe gastric transit, but oral formulations that control the spatiotemporal concentration of MBTs are yet to be developed, despite well-established connections between all therapeutics and their location, concentration, and distribution at sites of action. The development of a multi-functional polymer-based encapsulation system to formulate MBTs for enhanced storage and delivery through formulation of a model MBT, Lactobacillus casei ATCC393, is reported here. This approach enables the additive inclusion of excipients and polymers to grant specific functions, toward the development of a modular MBT platform. Through addition of established excipients, the formulation provides long-term storage of the encapsulated MBT. By adding higher molecular weight polymers, the release kinetics of the encapsulated MBTs can be modified. The inclusion of a mucoadhesive polymer significantly increases the adhesion force between the formulation and the intestinal tissue. Together, mucoadhesive and sustained release properties can be used to modulate the spatiotemporal concentration of MBTs. The formulation is compatible with standard oral capsules, thus maintaining existing clinical advantages of oral capsules while providing new functions from film encapsulation.

中文翻译：

用于治疗性微生物的封装、储存和可调释放的聚合物薄膜。

基于微生物的疗法（MBT）是一种治疗胃肠道感染和炎症性肠病的新兴治疗方式。目前用于口服MBT的制剂使用胶囊来实现安全的胃转运，但控制MBT时空浓度的口服制剂仍有待开发，尽管所有治疗方法及其在胃肠道部位的位置、浓度和分布之间已建立了良好的联系。行动。本文报道了一种基于多功能聚合物的封装系统的开发，该系统可通过配制模型 MBT（干酪乳杆菌 ATCC393）来配制 MBT，以增强储存和递送能力。这种方法能够添加赋形剂和聚合物以赋予特定功能，从而开发模块化 MBT 平台。通过添加已确定的赋形剂，该制剂可以长期保存封装的 MBT。通过添加较高分子量的聚合物，可以改变封装的 MBT 的释放动力学。粘膜粘附聚合物的加入显着增加了制剂和肠组织之间的粘附力。粘膜粘附和缓释特性可共同用于调节 MBT 的时空浓度。该配方与标准口服胶囊兼容，从而保持了口服胶囊现有的临床优势，同时提供了薄膜封装的新功能。

更新日期：2020-03-19

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