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Biological Behavior Regulation of Gold Nanoparticles via the Protein Corona.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-02-20 , DOI: 10.1002/adhm.201901448 Yu Ma 1 , Jin Hong 2 , Ya Ding 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-02-20 , DOI: 10.1002/adhm.201901448 Yu Ma 1 , Jin Hong 2 , Ya Ding 1
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One of the difficulties in the translation of gold nanoparticles (GNPs) into clinical practice is the formation of the protein corona (PC) that causes the discrepancy between the in vitro and in vivo performance of GNPs. The PC formed on the surface of GNPs gives them a biological identity instead of an initial synthetic one. In most instances, this biological identity increases the particle size, leads to more clearance by the reticuloendothelial system, and causes less uptake by target cells. However, the performance of GNPs can still be improved by rewriting their original surface chemistry via the PC. This review specifically focuses on discussing the main influence factors, including the biological environment and physicochemical properties of GNPs, which affect the production and status of the PC. The status of the PC such as the amount, thickness, and composition subsequently influence the biological behavior of GNPs, especially their cellular uptake, cytotoxicity, biodistribution, and tumor targeting. Further understanding and revealing the impacts of the PC on the biological behavior of GNPs can be a promising and important strategy to regulate and improve the performance of GNP-based biosystems in the future.
中文翻译：
金纳米粒子通过蛋白质电晕的生物行为调控。
金纳米颗粒（GNP）转化为临床实践的困难之一是蛋白电晕（PC）的形成，该蛋白引起了GNP的体外和体内性能之间的差异。在GNP表面形成的PC使它们具有生物学特性，而不是最初的合成物。在大多数情况下，这种生物学特性会增加粒径，导致网状内皮系统清除更多，并导致靶细胞摄取较少。但是，仍可以通过PC重写GNP的原始表面化学性质来提高GNP的性能。本文将重点讨论影响GPC的生产和状态的主要影响因素，包括GNP的生物学环境和理化特性。PC的状态，例如数量，厚度和组成随后会影响GNP的生物学行为，尤其是其细胞摄取，细胞毒性，生物分布和肿瘤靶向性。进一步了解和揭示PC对GNP生物学行为的影响可能是未来有希望且重要的策略，以调节和改善基于GNP的生物系统的性能。
更新日期：2020-03-19
中文翻译：
金纳米粒子通过蛋白质电晕的生物行为调控。
金纳米颗粒（GNP）转化为临床实践的困难之一是蛋白电晕（PC）的形成，该蛋白引起了GNP的体外和体内性能之间的差异。在GNP表面形成的PC使它们具有生物学特性，而不是最初的合成物。在大多数情况下，这种生物学特性会增加粒径，导致网状内皮系统清除更多，并导致靶细胞摄取较少。但是，仍可以通过PC重写GNP的原始表面化学性质来提高GNP的性能。本文将重点讨论影响GPC的生产和状态的主要影响因素，包括GNP的生物学环境和理化特性。PC的状态，例如数量，厚度和组成随后会影响GNP的生物学行为，尤其是其细胞摄取，细胞毒性，生物分布和肿瘤靶向性。进一步了解和揭示PC对GNP生物学行为的影响可能是未来有希望且重要的策略，以调节和改善基于GNP的生物系统的性能。
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