Polygenic liability for schizophrenia and childhood adversity influence daily‐life emotion dysregulation and psychosis proneness,Acta Psychiatrica Scandinavica

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Polygenic liability for schizophrenia and childhood adversity influence daily‐life emotion dysregulation and psychosis proneness
Acta Psychiatrica Scandinavica ( IF 5.3 ) Pub Date : 2020-02-21 , DOI: 10.1111/acps.13158
L-K Pries ₁ , B Klingenberg ₁ , C Menne-Lothmann ₁ , J Decoster _{1,

2,

3} , R van Winkel _{1,

2} , D Collip ₁ , P Delespaul ₁ , M De Hert _{2,

4} , C Derom _{5,

6} , E Thiery ₇ , N Jacobs _{1,

8} , M Wichers _{1,

9} , O Cinar ₁ , B D Lin ₁₀ , J J Luykx _{10,

11,

12} , B P F Rutten ₁ , J van Os _{1,

11,

13} , S Guloksuz _{1,

14}

Affiliation

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
Department of Neurosciences, University Psychiatric Centre KU Leuven, KU Leuven, Leuven, Belgium.
Brothers of Charity, University Psychiatric Centre Sint-Kamillus Bierbeek, Bierbeek, Belgium.
Antwerp Health Law and Ethics Chair - AHLEC, University Antwerp, Antwerp, Belgium.
Centre of Human Genetics, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Department of Obstetrics and Gynecology, Ghent University Hospitals, Ghent University, Ghent, Belgium.
Department of Neurology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Faculty of Psychology and Educational Sciences, Open University of the Netherlands, Heerlen, The Netherlands.
Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, The Netherlands.
Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
GGNet Mental Health, Apeldoorn, The Netherlands.
Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, London, UK.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.

To test whether polygenic risk score for schizophrenia (PRS‐S) interacts with childhood adversity and daily‐life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress‐sensitivity measures.

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