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Multifunctional composite hydrogel bolus with combined self-healing, antibacterial and adhesive functions for radiotherapy.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/02/21 , DOI: 10.1039/c9tb02967b Yi Hou 1 , Ying Song 2 , Xiaodong Sun 3 , Yulin Jiang 1 , Meiling He 1 , Yubao Li 1 , Xianchun Chen 4 , Li Zhang 1
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/02/21 , DOI: 10.1039/c9tb02967b Yi Hou 1 , Ying Song 2 , Xiaodong Sun 3 , Yulin Jiang 1 , Meiling He 1 , Yubao Li 1 , Xianchun Chen 4 , Li Zhang 1
Affiliation
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Radiotherapy is a commonly used method for curing cancers that appear on or just below the skin. Because of the dose build-up effect of X-rays, boluses made of various materials such as silica and wax are clinically applied on patients to increase the skin dose for an enhanced therapeutic effect. However, these commercial boluses can't conform well to the skin's surface with some curvature, resulting in radiation dose attenuation/loss at the lesion location. To address this limitation, we have developed a nano-titanium dioxide (nTiO2)-incorporated polyurethane/polyacrylamide (TPU/PAAm) hydrogel with multi-functions for fabricating a desirable bolus. The obtained hydrogel exhibits excellent mechanical, adhesive and self-healing properties and can fit closely to the surface of patients with any 3D curvature, eliminating the air gap which is a common problem for commercial boluses applied on patients. In particular, it is encouraging that when using the bolus made of TPU/PAAm hydrogel, the dose distribution including dose coverage, conformability and homogeneity within the planning target volume (PTV) is far superior to that when using the commercial bolus. A sufficient dose shifts toward the surface of the head model and is located only in the lesion site, demonstrating that TPU-PAAm hydrogel can provide an optimal dose distribution and be clinically effective for treating superficial tumors. Furthermore, nTiO2 particles feature uniform dispersion at the nanometer level in hydrogel after being modified by 2,2-bis(hydroxymethyl)propionic acid (DMPA) based on coordination chemistry, endowing the hydrogel with long-acting antibacterial ability. The good cell affinity of TPU-PAAm hydrogel is also confirmed in this study, further ensuring that the TPU-PAAm hydrogel prepared here is a desirable candidate as a tissue equivalent with the advantages of convenient use and effectiveness in radiotherapy.
中文翻译：
具有自愈，抗菌和粘合功能的多功能复合水凝胶推注，可用于放射治疗。
放射疗法是治疗出现在皮肤上或皮肤正下方的癌症的常用方法。由于X射线的剂量累积作用，临床上将由各种材料（例如二氧化硅和蜡）制成的大剂量推注到患者身上，以增加皮肤剂量以增强治疗效果。但是，这些商业性推注不能以一定的曲率很好地与皮肤表面吻合，从而导致病变部位的辐射剂量衰减/损失。为了解决这一局限性，我们开发了掺有纳米二氧化钛（nTiO2）的具有多种功能的聚氨酯/聚丙烯酰胺（TPU / PAAm）水凝胶，用于制备所需的推注。所获得的水凝胶具有出色的机械，粘合和自我修复性能，可以紧密贴合任何3D曲率的患者表面，消除气隙，这是对患者进行商业推注时常见的问题。尤其令人鼓舞的是，当使用由TPU / PAAm水凝胶制成的推注时，规划目标体积（PTV）内的剂量分布（包括剂量覆盖率，顺应性和均一性）远远优于使用市售推注。足够的剂量移向头部模型的表面，并且仅位于病变部位，这表明TPU-PAAm水凝胶可以提供最佳的剂量分布，并且在临床上可有效治疗浅表肿瘤。此外，nTiO2颗粒在基于配位化学被2,2-双（羟甲基）丙酸（DMPA）改性后，在纳米级的水凝胶中具有均匀的分散性，赋予水凝胶长效的抗菌能力。
更新日期：2020-04-01
中文翻译：
具有自愈，抗菌和粘合功能的多功能复合水凝胶推注，可用于放射治疗。
放射疗法是治疗出现在皮肤上或皮肤正下方的癌症的常用方法。由于X射线的剂量累积作用，临床上将由各种材料（例如二氧化硅和蜡）制成的大剂量推注到患者身上，以增加皮肤剂量以增强治疗效果。但是，这些商业性推注不能以一定的曲率很好地与皮肤表面吻合，从而导致病变部位的辐射剂量衰减/损失。为了解决这一局限性，我们开发了掺有纳米二氧化钛（nTiO2）的具有多种功能的聚氨酯/聚丙烯酰胺（TPU / PAAm）水凝胶，用于制备所需的推注。所获得的水凝胶具有出色的机械，粘合和自我修复性能，可以紧密贴合任何3D曲率的患者表面，消除气隙，这是对患者进行商业推注时常见的问题。尤其令人鼓舞的是，当使用由TPU / PAAm水凝胶制成的推注时，规划目标体积（PTV）内的剂量分布（包括剂量覆盖率，顺应性和均一性）远远优于使用市售推注。足够的剂量移向头部模型的表面，并且仅位于病变部位，这表明TPU-PAAm水凝胶可以提供最佳的剂量分布，并且在临床上可有效治疗浅表肿瘤。此外，nTiO2颗粒在基于配位化学被2,2-双（羟甲基）丙酸（DMPA）改性后，在纳米级的水凝胶中具有均匀的分散性，赋予水凝胶长效的抗菌能力。
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