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Promising antifungal agents: A minireview.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-02-21 , DOI: 10.1016/j.bmc.2020.115398 K V S Mani Chandrika 1 , Sahida Sharma 1
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-02-21 , DOI: 10.1016/j.bmc.2020.115398 K V S Mani Chandrika 1 , Sahida Sharma 1
Affiliation
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In the recent past, prevalence of life threatening fungal diseases have increased rapidly in immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer, organ transplant etc. Side by side, the appearance of drug resistance to the presently available antifungal therapeutics is on a rapid rise. It has become a top priority for the academia and pharmaceutical industries to develop new antifungal agents able to combat this resistance, and at the same time, possess potential broad spectrum of activity and minimum toxicity. An understanding of the pharmacological interactions between antifungal agents and their targets offers opportunities for design of new therapeutics. This review discusses the various methodology of drug design, structure activity relationships (SARs), and mode of action of variety of new antifungal agents.
中文翻译：
有希望的抗真菌药物：简要审查。
在最近的过去中，危及生命的真菌疾病在免疫功能低下的病例中迅速增加，例如获得性免疫缺陷综合症（AIDS），癌症，器官移植等。并列，对目前可用的抗真菌疗法的耐药性表现在迅速上升。开发能够抵抗这种耐药性的新型抗真菌剂，同时具有潜在的广谱活性和最低毒性，已成为学术界和制药行业的当务之急。对抗真菌剂及其靶标之间药理相互作用的理解为设计新的治疗方法提供了机会。这篇综述讨论了药物设计，结构活性关系（SAR）和各种新型抗真菌剂的作用方式的各种方法。
更新日期：2020-02-21
中文翻译：
有希望的抗真菌药物：简要审查。
在最近的过去中，危及生命的真菌疾病在免疫功能低下的病例中迅速增加，例如获得性免疫缺陷综合症（AIDS），癌症，器官移植等。并列，对目前可用的抗真菌疗法的耐药性表现在迅速上升。开发能够抵抗这种耐药性的新型抗真菌剂，同时具有潜在的广谱活性和最低毒性，已成为学术界和制药行业的当务之急。对抗真菌剂及其靶标之间药理相互作用的理解为设计新的治疗方法提供了机会。这篇综述讨论了药物设计，结构活性关系（SAR）和各种新型抗真菌剂的作用方式的各种方法。
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