Succinic acid is an industrially important platform chemical that could be used as precursor for the establishment of a sustainable chemical industry. Due to the depletion of crude oil and the need for sustainable development, the biological production of succinic acid from renewable resources has attracted wide attention. To establish an economical bio‐based succinic acid production process, various metabolic engineering strategies have been developed and applied to improve the strain performance, including efficient CO₂ fixation, by‐product elimination, use of metabolic modeling approaches, engineering of transcriptional regulations and optimization of reducing power balance. The utilization of renewable waste resources and the optimization of purification process have also been investigated to decrease the cost. This review will provide insights for current advances in succinic acid production and perspectives on further research to make bio‐based succinic acid production more efficient and economical. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd

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生物基琥珀酸：菌株开发，底物利用和下游纯化的概述

琥珀酸是工业上重要的平台化学品，可以用作建立可持续化学工业的前体。由于原油的枯竭和可持续发展的需要，利用可再生资源生物生产琥珀酸引起了广泛关注。为了建立一种经济的生物基琥珀酸生产工艺，已开发出各种代谢工程策略并将其应用于改善菌株性能，包括有效的CO ₂固定，副产物消除，代谢建模方法的使用，转录法规的工程设计和降低功率平衡的优化。为了降低成本，还研究了可再生废物资源的利用和纯化工艺的优化。这篇综述将为琥珀酸生产的最新进展提供见识，并为进一步研究使基于生物的琥珀酸生产更加有效和经济提供观点。©2019年化学工业协会和John Wiley＆Sons，Ltd