The biological production of succinic acid has attracted a great deal of attention due to the depletion of fossil fuels and concerns regarding environmental issues. As a natural producer of succinic acid, Actinobacillus succinogenes is one of the most promising candidates owning to its high production capability, wide carbon utilization spectrum, and robustness to environmental factors. This review details current achievements attempting to improve the efficiency of succinic acid production, not only in terms of raw materials and metabolic engineering strategies but also in terms of process optimization, such as work on neutralizing agents, redox potential, and the supply of CO₂. Strategies to reduce the accumulation of byproduct accumulation and to improve succinic acid synthesis are discussed. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.

中文翻译：

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琥珀酸放线杆菌对琥珀酸生产的综合研究：有前途的天然琥珀酸生产商

由于化石燃料的枯竭和对环境问题的关注，琥珀酸的生物生产引起了极大的关注。作为琥珀酸的天然生产者，琥珀酸放线杆菌由于其高生产能力，宽阔的碳利用谱以及对环境因素的鲁棒性而成为最有希望的候选者之一。这篇综述详细介绍了试图提高琥珀酸生产效率的当前成就，不仅在原料和代谢工程策略方面，而且在过程优化方面，例如中和剂，氧化还原电势和CO ₂的供应方面。讨论了减少副产物积累和改善琥珀酸合成的策略。©2019年化学工业协会和John Wiley＆Sons，Ltd.