In this work, a novel and high-efficiency scavenger based on amino-functionalized cellulose was designed for sodium cholate sorption in vitro. To estimate the adsorption performance of the amino-functionalized cellulose for sodium cholate, various factors including sodium cholate concentration, contact time and electrolyte were investigated. The results suggested that amino-functionalization for cellulose regarding to hyperbranched polyethylenimine not only induce positive charge surface of cellulose but also provide abundant and special binding sites for sodium cholate sorption. The amino-functionalized cellulose displayed an excellent performance to sodium cholate sorption with a maximum adsorption capacity of 569.7 mg/g, higher than cholestyramine, a synthetic lipid-lowering drug in clinic. And the adsorption behavior was well fitted into the Langmuir isotherm model and pseudo-second-order kinetic model, suggesting a homogeneous monolayer chemisorption. Furthermore, the amino-functionalized cellulose presented the features of excellent anti-interferences, cytocompatibility and facile preparation process. All these results support amino-functionalized cellulose as a promising prospect for cholesterol elimination.

在这项工作中，设计了一种基于氨基官能化纤维素的新型高效清除剂，用于体外胆酸钠的吸附。为了评估氨基官能化纤维素对胆酸钠的吸附性能，研究了胆酸钠的浓度，接触时间和电解质等各种因素。结果表明，与超支化聚乙烯亚胺有关的纤维素氨基官能化不仅诱导纤维素的正电荷表面，而且为胆酸钠的吸附提供了丰富而特殊的结合位点。氨基官能化纤维素对胆酸钠的吸附性能优异，最大吸附量为569.7 mg / g，高于临床合成的降脂药物消胆胺。吸附行为很好地拟合了Langmuir等温模型和伪二级动力学模型，表明均匀的单层化学吸附。此外，氨基官能化纤维素具有优异的抗干扰性，细胞相容性和制备工艺简便的特点。所有这些结果支持氨基官能化纤维素作为消除胆固醇的有希望的前景。