Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications.,Biomacromolecules

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Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-02-20 , DOI: 10.1021/acs.biomac.9b01754
Shoaib Iqbal _{1,

2} , Mark Blenner ₁ , Angela Alexander-Bryant ₂ , Jessica Larsen _{1,

2}

Affiliation

Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to poor absorption and rapid metabolism in the body. Polymersomes have tremendous potential in delivering these agents to their desired intracellular location due to increased circulation times, decreased macromolecule degradation, and decreased immune responses. In this Review, we highlight the key factors in design, development, and improved performance of these vesicles for macromolecular delivery. The recent progress made toward preclinical application of these vesicles for protein and gene delivery is also covered.

中文翻译：

用于蛋白质和核酸大分子治疗性递送的聚合物囊泡：从设计到治疗应用。

基于大分子的治疗剂，尤其是蛋白质，抗原，单克隆抗体，转录因子，核酸和基因编辑酶，具有为以前无法治愈的疾病提供治疗的潜力。然而，由于它们在体内的吸收差和新陈代谢快，它们提出了巨大的递送挑战。由于增加的循环时间，减少的大分子降解和减少的免疫应答，多聚体在将这些药物输送到所需的细胞内位置方面具有巨大的潜力。在这篇综述中，我们着重介绍了这些小分子用于大分子递送的设计，开发和改进性能的关键因素。这些囊泡用于蛋白质和基因递送的临床前应用的最新进展也包括在内。

更新日期：2020-02-20

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