Hub proteins are important elements of interactomes within an organism; they bind diverse partners, display significant pleiotropy, and connect many cellular systems. Static hubs interact with their partners simultaneously, while dynamic hubs bind different partners at different locations and times. Although this distinguishes some features of hub protein/partner interactions, the increasing literature requires an expanded categorization of molecular and functional properties. Here, we focus on dynein light chain LC8 as a canonical example of dynamic hub proteins to develop a conceptual residue-level framework for hub-partner interactions and functions. We propose a new class of structural linear motif-binding hub proteins (LMB-hubs) with key common features. LMB-hubs have structural plasticity yet conserved interfaces, can function as integral members of large multimolecular assemblies, and are self-regulating.

中文翻译：

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线性基序结合毂蛋白的新兴特征。

毂蛋白是生物体内相互作用组的重要元素。它们结合不同的伙伴，表现出显着的多效性，并连接许多细胞系统。静态集线器与它们的伙伴同时进行交互，而动态集线器在不同的位置和时间绑定不同的伙伴。尽管这区分了毂蛋白/伴侣相互作用的某些特征，但越来越多的文献要求对分子和功能特性进行扩展分类。在此，我们将动力蛋白轻链LC8视为动态毂蛋白的典范实例，以开发概念性的残基级框架以实现毂-伴侣相互作用和功能。我们提出了一类具有关键共同特征的结构线性基序结合毂蛋白（LMB-集线器）。LMB集线器具有结构可塑性但界面保守，