Signaling modules that integrate the diverse extra- and intracellular inputs to the Hippo pathway were previously unknown. By biochemical and molecular interrogation, Chen et al. established a molecular framework, the RhoA-RHPN-NF2/Kibra-STRIPAK axis, that regulates the status of Hippo core kinases and connects upstream signals to initiate and orchestrate the Hippo pathway.

中文翻译：

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STRIPAK是启动河马信号的监管中心

以前尚不清楚将多种多样的细胞外和细胞内输入整合到河马途径的信号传导模块。通过生物化学和分子询问，Chen等。建立了一个分子框架，即RhoA-RHPN-NF2 / Kibra-STRIPAK轴，可调节Hippo核心激酶的状态并连接上游信号以启动和协调Hippo途径。