Tuberculosis (TB) remains the leading cause of death from an infectious disease worldwide. TB therapy is complicated by the protracted treatment regimens, development of resistance coupled with toxicity and insufficient sterilizing capacity of current drugs. Although considerable progress has been made on establishing a TB drug pipeline, the high attrition rate reinforces the need to continually replenish the pipeline with high-quality leads that act through inhibition of novel targets. In this review, we highlight some of the key advances that have assisted TB drug discovery with novel chemical matter, targets and strategies - to fuel the TB drug pipeline.

中文翻译：

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对圣杯的追求：新的抗结核化学实体，目标和策略。

结核病（TB）仍然是全球传染病致死的主要原因。长期的治疗方案，耐药性的产生，毒性以及目前药物的杀菌能力不足使结核病治疗变得复杂。尽管在建立结核药物管道方面已经取得了可观的进展，但是高损耗率仍然需要不断补充高质量的铅，这些铅通过抑制新靶标而发挥作用。在这篇综述中，我们重点介绍了通过新化学物质，目标和策略协助结核病药物发现的一些关键进展，从而为结核病药物的研发提供了动力。