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Zeolites in drug delivery: Progress, challenges and opportunities.
Drug Discovery Today ( IF 6.5 ) Pub Date : 2020-02-13 , DOI: 10.1016/j.drudis.2020.02.005
Morteza Servatan 1 , Payam Zarrintaj 2 , Ghader Mahmodi 2 , Seok-Jhin Kim 2 , Mohammad Reza Ganjali 3 , Mohammad Reza Saeb 4 , Masoud Mozafari 5
Affiliation  

There are continuing attempts to achieve appropriate controlled-release therapeutic systems by designing innovative functional drug delivery systems (DDS). Although various types of delivery system have been developed, strategies that have successfully made it to the clinic are rare. Given their diverse structures, zeolites have attracted significant research attention for controlled and targeted drug delivery purposes. The structure of zeolites can be microporous, mesoporous or macroporous, which can be exploited to deliver a variety of therapeutic agents to the target site in a controlled manner. In this review, we introduce the different types of zeolite, and discuss the challenges and opportunities associated with their usage as drug delivery systems.

中文翻译:

药物输送中的沸石:进展,挑战和机遇。

通过设计创新的功能性药物递送系统(DDS),正在不断尝试实现适当的控释治疗系统。尽管已经开发了各种类型的输送系统,但很少有成功将其应用于临床的策略。鉴于其结构的多样性,出于控制和靶向药物输送的目的,沸石引起了广泛的研究关注。沸石的结构可以是微孔的,中孔的或大孔的,可以用来以控制方式将多种治疗剂递送至靶位。在这篇综述中,我们介绍了不同类型的沸石,并讨论了将其用作药物递送系统所带来的挑战和机遇。
更新日期:2020-02-13
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