Prevalence, incidence and residual risk of HIV, HCV and HBV are critical indicators of the safety of the blood supply. The American Red Cross routinely monitors these markers. Herein the results of testing over 58 million donations from 2007 to 2016 are reported. The prevalence and incidence of these infections has declined or remained essentially stable over the 7.5 to 10-year period.

In 2015 to 2016, the prevalence of HIV, HCV and HBV were respectively: 1.65, 11.47 and 5.85 per hundred thousand (pht) donations with a significant decrease over the 10-year study only for HCV. Weighted incidence rates for all positives were 1.98 pht person years (py) for HIV, 2.20 pht py for HCV and 1.25 pht py for HBV. Estimates of residual risk using these incidence rates were: HIV, 1:2.3 million; HCV, 1:2.6 million; and HBV, 1:1.5 million donations, reflecting very low risk to recipients. There have been increases in the safety of the blood supply compared to prior published estimates. Demographic factors were shown to be associated with variations in infection prevalence and incidence. Continuing changes in the structure of the donor population or changes in policy could impact these measures of safety.

HIV，HCV和HBV的患病率，发病率和残留风险是血液供应安全的关键指标。美国红十字会定期监视这些标记。本文报告了2007年至2016年超过5800万笔捐款的测试结果。这些感染的发生率和发生率在7.5到10年间已经下降或基本保持稳定。

在2015年至2016年，HIV，HCV和HBV的流行率分别为：每十万（pht）捐赠1.65、11.47和5.85，与仅针对HCV的10年研究相比有显着下降。所有阳性病毒的加权发生率分别为：艾滋病毒1.98 pht人年（py），丙肝病毒2.20 pht py年和乙肝病毒1.25 pht py。使用这些发病率估算的残留风险为：艾滋病毒：1,230万；HCV，1：260万；和HBV，捐款比例为1：150万，这反映了接受者的风险非常低。与先前公布的估计相比，血液供应的安全性有所提高。人口统计学因素与感染发生率和发生率的变化有关。捐助者人口结构的不断变化或政策的变化可能会影响这些安全措施。