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A Theoretical Framework for Evolutionary Cell Biology.
Journal of Molecular Biology ( IF 4.7 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.jmb.2020.02.006 Michael Lynch 1 , Bogi Trickovic 1
Journal of Molecular Biology ( IF 4.7 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.jmb.2020.02.006 Michael Lynch 1 , Bogi Trickovic 1
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One of the last uncharted territories in evolutionary biology concerns the link with cell biology. Because all phenotypes ultimately derive from events at the cellular level, this connection is essential to building a mechanism-based theory of evolution. Given the impressive developments in cell biological methodologies at the structural and functional levels, the potential for rapid progress is great. The primary challenge for theory development is the establishment of a quantitative framework that transcends species boundaries. Two approaches to the problem are presented here: establishing the long-term steady-state distribution of mean phenotypes under specific regimes of mutation, selection, and drift and evaluating the energetic costs of cellular structures and functions. Although not meant to be the final word, these theoretical platforms harbor potential for generating insight into a diversity of unsolved problems, ranging from genome structure to cellular architecture to aspects of motility in organisms across the Tree of Life.
中文翻译：
进化细胞生物学的理论框架。
进化生物学中最后一个未知领域之一是与细胞生物学的联系。由于所有表型最终都来自细胞水平的事件，因此这种联系对于建立基于机制的进化论至关重要。鉴于细胞生物学方法在结构和功能水平上的惊人发展，迅速发展的潜力是巨大的。理论发展的主要挑战是建立超越物种边界的定量框架。这里提出了解决该问题的两种方法：在特定的突变，选择和漂移机制下，建立平均表型的长期稳态分布，并评估细胞结构和功能的能量消耗。虽然这不是硬道理，
更新日期：2020-02-20
中文翻译：
进化细胞生物学的理论框架。
进化生物学中最后一个未知领域之一是与细胞生物学的联系。由于所有表型最终都来自细胞水平的事件，因此这种联系对于建立基于机制的进化论至关重要。鉴于细胞生物学方法在结构和功能水平上的惊人发展，迅速发展的潜力是巨大的。理论发展的主要挑战是建立超越物种边界的定量框架。这里提出了解决该问题的两种方法：在特定的突变，选择和漂移机制下，建立平均表型的长期稳态分布，并评估细胞结构和功能的能量消耗。虽然这不是硬道理，
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