BACKGROUND Despite advances in transplantation medicine, psychological distress, quality of life and functional deficits continue to compromise survivorship after hematopoietic stem cell transplantation (HSCT). With increasing numbers of HSCT survivors, supportive oncology interventions that target health-related outcomes in HSCT survivorship are needed. Hence, we aimed to test the feasibility and acceptability of a group format phone-delivered positive psychology (PP) intervention in HSCT survivors. METHODS This is a one-arm pilot study design that adapted and tested an individual PP intervention used in cardiac disease to a phone-delivered group-based program for HSCT survivors who were 0.4 to 39 years post-transplant. All participants received the 8-session weekly PP intervention. We assessed feasibility by the enrollment and intervention completion rates. We examined acceptability on a 10-point Likert scale of ease and utility. Unstructured qualitative interviews were used to obtain participant feedback on the intervention for future application in a larger trial. Self-reported assessments on psychological, functional, and quality of life outcomes were administered at baseline and at follow-up (the end of the intervention). RESULTS Of 64 eligible participants, 29 (45%) enrolled in the study. For the main aim of intervention feasibility and acceptability, participants completed 96% of all PP sessions and participants rated the ease (7.6 [SD 1.7]) and utility (8.1 [SD 1.1]) of sessions highly. Of the self-reported assessments obtained, the PP intervention resulted in improvements in the resilience scale (mean difference 2.4 [SD 5.4], p=0.03). From unstructured qualitative interviews, participants reported the PP exercises and intervention helped them to focus on positive emotions and the group format fostered a sense of community and social support. CONCLUSION An 8-week phone-delivered group format PP intervention is feasible and acceptable in HSCT survivors. The piloted intervention could be tested with minor modifications in a randomized study to definitively examine the impact of the group format PP intervention on health-related outcomes.

中文翻译：

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通过积极的心理干预改善造血干细胞移植幸存者的生活质量。

背景技术尽管在移植医学方面取得了进步，但造血干细胞移植（HSCT）后的心理困扰，生活质量和功能缺陷仍继续损害存活率。随着HSCT幸存者数量的增加，需要针对HSCT幸存者健康相关结果的支持性肿瘤干预措施。因此，我们旨在测试在HSCT幸存者中采用小组形式的电话传递积极心理学（PP）干预的可行性和可接受性。方法这是一项单臂试点研究设计，该设计将针对心脏病的个人PP干预措施进行了调整，并针对移植后0.4至39年的HSCT幸存者进行了电话传递的基于小组的计划。所有参与者均接受为期8周的PP每周干预。我们通过入组和干预完成率评估了可行性。我们在简易性和实用性的10点Likert量表上检查了可接受性。使用非结构化的定性访谈来获取参与者对干预措施的反馈，以便将来在更大的试验中应用。在基线和随访时（干预结束时）进行关于心理，功能和生活质量的自我报告评估。结果在64位合格参与者中，有29位（45％）参与了研究。出于干预可行性和可接受性的主要目的，参与者完成了所有PP会话的96％，并且参与者对会话的易用性（7.6 [SD 1.7]）和实用性（8.1 [SD 1.1]）给予了高度评价。在获得的自我报告的评估中，PP干预导致了复原力量表的改善（平均差异为2）。4 [SD 5.4]，p = 0.03）。通过非结构化的定性访谈，参与者报告了PP练习和干预帮助他们专注于积极情绪，而小组形式则培养了社区和社会支持感。结论在HSCT幸存者中进行为期8周的电话传递小组格式PP干预是可行且可接受的。可以在随机研究中对试验性干预措施进行较小的改动来进行测试，以明确检查小组形式的PP干预措施对健康相关结果的影响。结论在HSCT幸存者中进行为期8周的电话传递小组格式PP干预是可行且可接受的。可以在随机研究中对试验性干预措施进行较小的改动来进行测试，以明确检查小组形式的PP干预措施对健康相关结果的影响。结论在HSCT幸存者中进行为期8周的电话传递小组格式PP干预是可行且可接受的。可以在随机研究中对试验性干预措施进行较小的改动来进行测试，以明确检查小组形式的PP干预措施对健康相关结果的影响。