Targeted activation of spinal respiratory neural circuits.,Experimental Neurology

当前位置： X-MOL 学术 › Exp. Neurol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Targeted activation of spinal respiratory neural circuits.
Experimental Neurology ( IF 4.6 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.expneurol.2020.113256
Michael D Sunshine ₁ , Tommy W Sutor ₂ , Emily J Fox ₃ , David D Fuller ₄

Affiliation

Spinal interneurons which discharge in phase with the respiratory cycle have been repeatedly described over the last 50 years. These spinal respiratory interneurons are part of a complex propriospinal network that is synaptically coupled with respiratory motoneurons. This article summarizes current knowledge regarding spinal respiratory interneurons and emphasizes chemical, electrical and physiological methods for activating spinal respiratory neural circuits. Collectively, the work reviewed here shows that activating spinal interneurons can have a powerful impact on spinal respiratory motor output, and can even drive rhythmic bursting in respiratory motoneuron pools under certain conditions. We propose that primary functions of spinal respiratory neurons include 1) shaping the respiratory pattern into the final efferent motor output from the spinal respiratory nerves; 2) coordinating respiratory muscle activation across the spinal neuraxis; 3) coordinating postural, locomotor and respiratory movements, and 4) enabling plasticity of respiratory motor output in health and disease.

中文翻译：

脊髓呼吸神经回路的靶向激活。

在过去的 50 年中反复描述了与呼吸周期同步放电的脊髓中间神经元。这些脊髓呼吸中间神经元是与呼吸运动神经元突触耦合的复杂本体脊髓网络的一部分。本文总结了当前有关脊髓呼吸中间神经元的知识，并强调了激活脊髓呼吸神经回路的化学、电学和生理学方法。总的来说，这里回顾的工作表明，激活脊髓中间神经元可以对脊髓呼吸运动输出产生强大的影响，甚至可以在某些条件下驱动呼吸运动神经元池的节律性爆发。我们提出脊髓呼吸神经元的主要功能包括：1）将呼吸模式塑造成脊髓呼吸神经的最终传出运动输出；2) 协调整个脊神经轴的呼吸肌激活；3) 协调姿势、运动和呼吸运动，以及 4) 在健康和疾病中实现呼吸运动输出的可塑性。

更新日期：2020-02-20

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11