The relationship between personality profiles and brain integrity in old age is still a matter of debate. We examined the association between Big Five factor and facet scores and MRI brain volume changes on a 54-month follow-up in 65 elderly controls with 3 neurocognitive assessments (baseline, 18 months, and 54 months), structural brain MRI (baseline and 54 months), brain amyloid PET during follow-up, and APOE genotyping. Personality was assessed with the Neuroticism Extraversion Openness Personality Inventory-Revised. Regression models were used to identify predictors of volume loss including time, age, sex, personality, amyloid load, presence of APOE ε4 allele, and cognitive evolution. Lower agreeableness factor scores (and 4 of its facets) were associated with lower volume loss in the hippocampus, entorhinal cortex, amygdala, mesial temporal lobe, and precuneus bilaterally. Higher openness factor scores (and 2 of its facets) were also associated with lower volume loss in the left hippocampus. Our findings persisted when adjusting for confounders in multivariable models. These data suggest that the combination of low agreeableness and high openness is an independent predictor of better preservation of brain volume in areas vulnerable to neurodegeneration.

中文翻译：

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不太讨人喜欢，保存得更好？基于社区的队列中的 PET 淀粉样蛋白和 MRI 研究

老年人格特征与大脑完整性之间的关系仍然是一个有争议的问题。我们通过 3 项神经认知评估（基线、18 个月和 54 个月）、结构性脑 MRI（基线和 54月）、随访期间的脑淀粉样蛋白 PET 和 APOE 基因分型。人格通过神经质外向性开放性人格量表-修订版进行评估。回归模型用于确定体积损失的预测因素，包括时间、年龄、性别、个性、淀粉样蛋白负荷、APOE ε4 等位基因的存在和认知进化。较低的宜人性因素评分（及其 4 个方面）与海马、内嗅皮层、杏仁核、双侧颞叶内侧和楔前叶。较高的开放因子得分（及其 2 个方面）也与左侧海马体的体积损失较低有关。在调整多变量模型中的混杂因素时，我们的发现仍然存在。这些数据表明，低宜人性和高开放性的结合是在容易发生神经变性的区域更好地保存脑容量的独立预测因素。