Cellular energy demands are readily changed during physical exercise resulting in adaptive responses by signaling proteins of metabolic processes, including the NAD⁺ dependent lysine deacetylase SIRT1. Regular exercise results in systemic adaptation that restores the level of SIRT1 in the kidney, liver, and brain in patients with neurodegenerative diseases, and thereby normalizes cellular metabolic processes to attenuate the severity of these diseases. In skeletal muscle, over-expression of SIRT1 results in enhanced numbers of myonuclei improves the repair process after injury and is actively involved in muscle hypertrophy by up-regulating anabolic and downregulating catabolic processes. The present review discusses the different views of SIRT1 dependent deacetylation of PGC-α.

在体育锻炼期间，细胞能量需求很容易改变，从而通过代谢过程的信号蛋白（包括 NAD ⁺依赖性赖氨酸脱乙酰酶 SIRT1）产生适应性反应。定期运动会导致全身适应，从而恢复神经退行性疾病患者肾脏、肝脏和大脑中 SIRT1 的水平，从而使细胞代谢过程正常化，从而减轻这些疾病的严重程度。在骨骼肌中，SIRT1 的过度表达导致肌核数量增加，从而改善了损伤后的修复过程，并通过上调合成代谢和下调分解代谢过程积极参与肌肉肥大。本综述讨论了 SIRT1 依赖的 PGC-α 去乙酰化的不同观点。