Hepatocellular carcinoma (HCC), the main cause of liver cancer-related death, is one of the main cancers in terms of incidence and mortality. However, HCC is difficult to target and develops strong drug resistance. Therefore, a new treatment strategy is urgently needed. The clinical application of the concept of synthetic lethality in recent years provides a new therapeutic direction for the accurate treatment of HCC. Here, we introduce the concept of synthetic lethality, the screening used to study synthetic lethality, and the identified and potential genetic interactions that induce synthetic lethality in HCC. In addition, we propose opportunities and challenges for translating synthetic lethal interactions to the clinical treatment of HCC.

中文翻译：

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合成杀伤力：肝细胞癌的一种有前途的治疗策略。

就肝癌相关死亡的主要原因而言，肝细胞癌（HCC）是发病率和死亡率方面的主要癌症之一。但是，HCC难以靶向并且会产生强大的耐药性。因此，迫切需要一种新的治疗策略。近年来，合成致死性概念的临床应用为肝癌的准确治疗提供了新的治疗方向。在这里，我们介绍了合成致死性的概念，用于研究合成致死性的筛选以及已鉴定出的和潜在的在HCC中引起合成致死性的遗传相互作用。此外，我们提出了将合成致死相互作用转化为肝癌临床治疗的机遇和挑战。