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Respiratory complex I - structure, mechanism and evolution.
Current Opinion in Structural Biology ( IF 6.1 ) Pub Date : 2020-02-10 , DOI: 10.1016/j.sbi.2020.01.004
Kristian Parey 1 , Christophe Wirth 2 , Janet Vonck 3 , Volker Zickermann 4
Affiliation  

Respiratory complex I is an intricate multi-subunit membrane protein with a central function in aerobic energy metabolism. During the last years, structures of mitochondrial complex I and respiratory supercomplexes were determined by cryo-EM at increasing resolution. Structural and computational studies have shed light on the dynamics of proton translocation pathways, the interaction of complex I with lipids and the unusual access pathway of ubiquinone to the active site. Recent advances in understanding complex I function include characterization of specific conformational changes that are critical for proton pumping. Cryo-EM structures of the NADH dehydrogenase-like (NDH) complex of photosynthesis and a bacterial membrane bound hydrogenase (MBH) have provided a broader perspective on the complex I superfamily.

中文翻译:

呼吸系统综合症I-结构,机制和进化。

呼吸复合物I是复杂的多亚基膜蛋白,在有氧能量代谢中具有重要作用。在最近几年中,线粒体复合体I和呼吸超复合体的结构是通过冷冻电磁法以增加的分辨率确定的。结构和计算研究揭示了质子易位途径的动力学,复合物I与脂质的相互作用以及泛醌到达活性位点的异常通路。了解复杂I功能的最新进展包括表征特定构象变化,这对于质子泵浦至关重要。光合作用的NADH脱氢酶样(NDH)复合物和细菌膜结合氢化酶(MBH)的低温EM结构为复合物I超家族提供了更广阔的前景。
更新日期:2020-02-10
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