Purpose

To investigate the difference in longitudinal change of ß-zone parapapillary atrophy (PPA) between eyes with primary open-angle glaucoma (POAG) and normal eyes.

Design

Longitudinal, observation study.

Participants

A total of 153 eyes with POAG and 105 normal eyes.

Methods

Participants were followed for 10 years or more, with disc photography performed every year. The topographic parameters of ß-zone PPA (area, maximal radial extent, angular extent around disc) were measured. The factors associated with the enlargement of ß-zone PPA parameters were assessed by odds ratio (OR) using multivariable logistic regression.

Main Outcome Measures

Enlargement of ß-zone PPA parameters and associated factors.

Results

Over the course of the average 11.6±1.3-year follow-up period, enlargement of β-zone PPA was detected in 66.7% of POAG eyes and in 26.7% of normal eyes. Increment of all PPA parameters was significantly more common in cases of POAG than in normal eyes (all P < 0.001). The spatial distribution of maximal radial extent at baseline and final examination was significantly different between the 2 groups: POAG eyes; inferotemporal versus normal eyes; temporal (chi-square = 26.549, P < 0.001, chi-square = 19.320, P = 0.004, respectively). The widening of radial extent was significantly associated with older age (OR, 1.036; P = 0.010) and the presence of glaucoma (OR, 2.599; P = 0.002). The increment of angular extent was associated with the presence of glaucoma (OR, 12.167; P = 0.017) and optic disc hemorrhage (OR, 3.266; P = 0.019).

Conclusions

The pattern of ß-zone PPA change differed between POAG and normal eyes during a follow-up of 10 years or more. The enlargement of PPA occurred more frequently in POAG than in normal eyes. The widening of radial extent was associated with older age and glaucoma, whereas the increment of angular extent was associated with glaucomatous damage.

中文翻译：

---

十年及ß区乳头旁萎缩症的纵向变化：原发性开角型青光眼与正常眼的比较。

目的

研究原发性开角型青光眼（POAG）的眼睛与正常眼睛在β区乳头状旁萎缩（PPA）的纵向变化上的差异。

设计

纵向观察研究。

参加者

POAG共153眼，正常眼105。

方法

参与者被跟踪了10年或更长时间，每年进行光盘摄影。测量了ß区PPA的地形参数（面积，最大径向范围，圆盘周围的角度范围）。使用多元逻辑回归，通过比值比（OR）评估与ß区PPA参数扩大相关的因素。

主要观察指标

扩大ß区PPA参数和相关因素。

结果

在平均11.6±1.3年的随访过程中，有66.7％的POAG眼和26.7％的正常眼发现了β区PPA增大。在POAG中，所有PPA参数的增加比正常人的眼睛更为常见（所有P <0.001）。两组之间在基线和最终检查时最大radial骨范围的空间分布有显着差异。颞下与正常眼 时间（卡方= 26.549，P <0.001，卡方= 19.320，P  = 0.004）。radial骨范围的扩大与年龄较大（OR，1.036；P  = 0.010）和青光眼的存在（OR，2.599；P）显着相关。 = 0.002）。角范围的增加与青光眼的存在（OR，12.167；P  = 0.017）和视盘出血（OR，3.266；P  = 0.019）有关。

结论

在10年或更长时间的随访中，POAG和正常眼睛的ß区PPA变化模式不同。与正常眼睛相比，POAG中PPA增大的频率更高。radial骨范围的扩大与老年人和青光眼有关，而角范围的增加与青光眼损害有关。