BACKGROUND The aim of this meta-analysis is to evaluate the association of fibrinogen with risk of dementia and its subtypes. METHODS Embase, Pubmed and Web of Science were retrieved systematically up to February 2019. Standard mean difference (SMD) with 95 % confidence intervals was estimated using random-effects models. RESULTS Sixteen studies involving 3,649 participants were summarized. Patients with all-cause dementia exhibited higher fibrinogen levels than those in non-dementia controls (SMD = 0.90 [0.43;1.36] p < 0.01). Further subgroup analysis revealed a positive association of fibrinogen with vascular dementia (VaD) (SMD = 1.11 [0.45;1.78] p < 0.01) rather than Alzheimer's disease (AD) (SMD = 0.01 [-0.17;0.19]) p = 0.92) and Parkinson's disease dementia (PDD) (SMD = 0.35 [-0.23;0.93] p = 0.24). This correlation was significant in Europeans (SMD = 0.92 [0.34;1.49] p < 0.01), but probably not in Asian based populations (SMD = 1.04 [-0.09;2.17] p = 0.07), and gradually declined with advancing age (60 ≤ age < 70: SMD = 1.22 [0.38;2.06] p < 0.01; 70 ≤ age < 80: SMD = 0.29 [0.04;0.53] p = 0.02; age ≥ 80: SMD = 0.01 [-0.12;0.15] p = 0.84). CONCLUSIONS Plasma fibrinogen is a potential risk factor for all-cause dementia and VaD under the age of 80, and is more obvious in cohorts with people of European descent.

中文翻译：

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纤维蛋白原与痴呆的风险：系统评价和荟萃分析。

背景这项荟萃分析的目的是评估纤维蛋白原与痴呆风险及其亚型的关系。方法直到2019年2月，系统地检索Embase，Pubmed和Web of Science。使用随机效应模型估算置信区间为95％的标准均差（SMD）。结果总结了16项研究，涉及3,649名参与者。全因痴呆症患者的纤维蛋白原水平高于非痴呆对照者（SMD = 0.90 [0.43; 1.36] p <0.01）。进一步的亚组分析显示纤维蛋白原与血管性痴呆（VaD）呈正相关（SMD = 1.11 [0.45; 1.78] p <0.01）而非阿尔茨海默氏病（AD）（SMD = 0.01 [-0.17; 0.19]）p = 0.92）和帕金森氏病痴呆症（PDD）（SMD = 0.35 [-0.23; 0.93] p = 0.24）。这种相关性在欧洲人中很显着（SMD = 0.92 [0.34; 1.49] p <0.01），但在亚洲人群中可能没有（SMD = 1.04 [-0.09; 2.17] p = 0.07），并且随着年龄的增长而逐渐下降（60） ≤年龄<70：SMD = 1.22 [0.38; 2.06] p <0.01; 70≤年龄<80：SMD = 0.29 [0.04; 0.53] p = 0.02;年龄≥80：SMD = 0.01 [-0.12; 0.15] p = 0.84）。结论血浆纤维蛋白原是80岁以下全因痴呆和VaD的潜在危险因素，在欧洲血统人群中更为明显。