Vascular calcification is a life-threatening complication in patients with chronic kidney disease. Magnesium is a potent inhibitor of calcification and attracting attention as a new therapeutic candidate. ter Braake and colleagues demonstrate that magnesium supplementation strikingly prevents vascular calcification in Klotho knockout mice. However, these mice also show osteomalacia, indicating that magnesium has a Janus face. Maximizing the beneficial effects of magnesium without causing bone mineralization defects is an important next challenge.

中文翻译：

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镁是一种面对Janus的钙化抑制剂。

血管钙化是慢性肾脏病患者的危及生命的并发症。镁是有效的钙化抑制剂，作为一种新的治疗候选物引起了人们的关注。ter Braake及其同事证明，补充镁可显着阻止Klotho基因敲除小鼠的血管钙化。但是，这些小鼠也显示出骨软化症，表明镁具有Janus脸。在不引起骨骼矿化缺陷的情况下最大化镁的有益作用是下一个重要的挑战。